A Thioether-Ligated Cupric Superoxide Model with Hydrogen Atom Abstraction Reactivity

• Published in: Journal of the American Chemical Society Vol. 143; no. 10; pp. 3707 - 3713
• Main Authors: Bhadra, Mayukh, Transue, Wesley J, Lim, Hyeongtaek, Cowley, Ryan E, Lee, Jung Yoon C, Siegler, Maxime A, Josephs, Patrick, Henkel, Gerald, Lerch, Markus, Schindler, Siegfried, Neuba, Adam, Hodgson, Keith O, Hedman, Britt, Solomon, Edward I, Karlin, Kenneth D
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 17.03.2021; American Chemical Society (ACS)
• Subjects: Copper - chemistry; Density Functional Theory; Extended X-ray absorption fine structure; Hydrogen - chemistry; INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Kinetics; Ligands; Molecular Conformation; Oxidation-Reduction; Oxides; Peptides and proteins; Reactivity; Spectrophotometry, Ultraviolet; Spectroscopy; Sulfides - chemistry; Superoxides - chemistry

The central role of cupric superoxide intermediates proposed in hormone and neurotransmitter biosynthesis by noncoupled binuclear copper monooxygenases like dopamine-β-monooxygenase has drawn significant attention to the unusual methionine ligation of the CuM (“CuB”) active site characteristic of th...