Phosphinoyl Radical Initiated Vicinal Cyanophosphinoylation of Alkenes

• Published in: Organic letters Vol. 19; no. 20; pp. 5537 - 5540
• Main Authors: Zhang, Pei-Zhi, Zhang, Ling, Li, Jian-An, Shoberu, Adedamola, Zou, Jian-Ping, Zhang, Wei
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 20.10.2017; Amer Chemical Soc
• Subjects: alkenes; chemical reactions; chemical structure; Chemistry; Chemistry, Organic; manganese; Physical Sciences; Science & Technology; C-P BOND; PHOSPHORUS-CENTERED RADICALS; CROSS-COUPLING REACTIONS; FACILE SYNTHESIS; CARBON BOND; LIGANDS; OXYPHOSPHORYLATION; BETA-HYDROXYPHOSPHONATES; ALKYNES; UNACTIVATED ALKENES

A double-functionalization reaction of alkenes through Mn­(OAc)3-mediated phosphinoyl radical addition followed by CuCN-catalyzed cyanation is introduced. This one-pot reaction is performed under mild conditions to afford vicinal cyanophosphinoylation products.