Asymmetric Total Syntheses and Biological Studies of Tuberostemoamide and Sessilifoliamide A

• Published in: Organic letters Vol. 21; no. 8; pp. 2952 - 2956
• Main Authors: Hou, Yongsheng, Shi, Tao, Yang, Yuhang, Fan, Xiaohong, Chen, Jinhong, Cao, Fei, Wang, Zhen
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 19.04.2019; Amer Chemical Soc
• Subjects: alkaloids; chemical reactions; chemical structure; Chemistry; Chemistry, Organic; cholinesterase; neurodegenerative diseases; Physical Sciences; Science & Technology; Stemona; stereochemistry; stereoselectivity; ALKALOIDS

The first asymmetric total syntheses of tuberostemoamide, sessilifoliamide A, and their epimers have been accomplished via the common intermediate ethylstemoamide. The stereochemistry control relationship at C8/C9/C10 of ethylstemoamide is clearly revealed for the first time, and a subtle difference...