Current and Novel Approaches to the Drug Treatment of Schizophrenia

• Published in: Journal of medicinal chemistry Vol. 44; no. 4; pp. 477 - 501
• Main Authors: Rowley, Michael, Bristow, Linda J, Hutson, Peter H
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 15.02.2001
• Subjects: Animals; Antipsychotic Agents - adverse effects; Antipsychotic Agents - pharmacology; Antipsychotic Agents - therapeutic use; Biological and medical sciences; Cholinergic Agonists - adverse effects; Cholinergic Agonists - pharmacology; Cholinergic Agonists - therapeutic use; Disease Models, Animal; Dopamine Antagonists - adverse effects; Dopamine Antagonists - pharmacology; Dopamine Antagonists - therapeutic use; Enzyme Inhibitors - adverse effects; Enzyme Inhibitors - pharmacology; Enzyme Inhibitors - therapeutic use; Excitatory Amino Acid Antagonists - adverse effects; Excitatory Amino Acid Antagonists - pharmacology; Excitatory Amino Acid Antagonists - therapeutic use; Humans; Medical sciences; Mice; Mice, Transgenic; Neuropharmacology; Nitric Oxide Synthase - antagonists & inhibitors; Pharmacology. Drug treatments; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Receptor, Serotonin, 5-HT2A; Receptors, AMPA - antagonists & inhibitors; Receptors, Dopamine D2 - drug effects; Receptors, Dopamine D4; Receptors, Metabotropic Glutamate - antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Receptors, Neurotensin - agonists; Receptors, Serotonin - drug effects; Schizophrenia - drug therapy; Schizophrenia - etiology; Schizophrenia - metabolism; Serotonin Antagonists - adverse effects; Serotonin Antagonists - pharmacology; Serotonin Antagonists - therapeutic use; D4 Dopamine receptor; Ligand; Psychotropic; Toxicity; Schizophrenia; Glutamate receptor; Review; Neurotensin; 5-HT2 Serotonine receptor; Psychosis; Chemotherapy; Cholinergic receptor; Treatment; Metabotropic receptor; Secondary effect; Peptidergic receptor; Antipsychotic; Atypical; Muscarinic receptor; Antagonist; Tachykinin receptor; NMDA receptor