Comparative Absorption of a Standardized Curcuminoid Mixture and Its Lecithin Formulation

• Published in: Journal of natural products (Washington, D.C.) Vol. 74; no. 4; pp. 664 - 669
• Main Authors: Cuomo, John, Appendino, Giovanni, Dern, Adam S, Schneider, Erik, McKinnon, Toni P, Brown, Mark J, Togni, Stefano, Dixon, Brian M
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society and American Society of Pharmacognosy 25.04.2011; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Analysis; Biological and medical sciences; Chemistry, Medicinal; Chemistry, Pharmaceutical; Curcumin - analogs & derivatives; Curcumin - chemistry; Curcumin - pharmacokinetics; Curcumin - standards; Diarylheptanoids; General pharmacology; Humans; Lecithins - pharmacokinetics; Lecithins - standards; Life Sciences & Biomedicine; Medical sciences; Molecular Structure; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Reference Standards; Science & Technology; EFFICACY; BLACK PEPPER; INFLAMMATION; PIPERINE; DOWN-REGULATION; LIPOPOLYSACCHARIDE; OSTEOARTHRITIS; PHOSPHATIDYLCHOLINE; MAJOR CONSTITUENT; DEMETHOXYCURCUMIN; Human; Biological fluid; Healthy subject; Phospholipid; Complex lipid; Mixture; Property formulation relationship; Blood; Blood plasma; Organic pigment; Absorption; Dosage form; Phosphatidylcholine; Pharmacokinetics; Comparative study

The relative absorption of a standardized curcuminoid mixture and its corresponding lecithin formulation (Meriva) was investigated in a randomized, double-blind, crossover human study. Clinically validated dosages were used for both products, and plasma levels of all three major curcuminoids [curcum...