Proteomic Exploration of Membrane Curvature Sensors Using a Series of Spherical Supported Lipid Bilayers

• Published in: Analytical chemistry (Washington) Vol. 92; no. 24; pp. 16197 - 16203
• Main Authors: Tanaka, Masayoshi, Komikawa, Takumi, Yanai, Kentaro, Okochi, Mina
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 15.12.2020
• Subjects: Amino acid sequence; Binders; Binding; Biological membranes; Biomarkers; Breast cancer; Cell Line, Tumor; Chemistry; Cluster analysis; Clustering; Curvature; Fibroblasts - metabolism; Homology; Humans; Lipid bilayers; Lipid Bilayers - chemistry; Lipid Bilayers - metabolism; Lipids; Membrane proteins; Membrane Proteins - metabolism; Membranes; Morphology; Orthology; Proteins; Proteomics; Sensors; Silicon dioxide; Silybin - chemistry

Membrane curvature-sensing (MCS) proteins recognize and regulate the morphologies of biological membranes. As these proteins lack characteristic sequence motifs in their primary structure, they are not instantly recognizable by genomic databases. Overcoming this technological challenge toward the ag...