R-Type Fonticins Produced by Pragia fontium Form Large Pores with High Conductance

• Published in: Journal of bacteriology Vol. 205; no. 1; p. e0031522
• Main Authors: Látrová, Klára, Dolejšová, Tereza, Motlová, Lucia, Mikušová, Gabriela, Bosák, Juraj, Snopková, Kateřina, Šmajs, David, Konopásek, Ivo, Fišer, Radovan
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 26.01.2023
• Subjects: Bacteria; Bacteriocins; Bacteriocins - metabolism; Bacteriology; Black lipid membranes; Cell Membrane - metabolism; Cell walls; Conductance; Contractility; Enterobacteriaceae; Gram-negative bacteria; Lipid Bilayers - metabolism; Lipid membranes; Lipids; Macromolecules; Membranes; Phages; Polyethylene glycol; Pore formation; Pores; Research Article; Sodium chloride; Sodium Chloride - metabolism; Transmission electron microscopy; electric current; black lipid membranes; electron microscopy; membrane pore formation; fonticin; phage tail-like bacteriocins; single-pore conductance; conductance

Phage tail-like bacteriocins are now the subject of research as potent antibacterial agents due to their narrow host specificity and single-hit mode of action. In this work, we focused on the structure and mode of action of fonticins. Fonticins are phage tail-like bacteriocins produced by the Gram-n...