Synthesis and Characterization of Degradable Polar Hydrophobic Ionic Polyurethane Scaffolds for Vascular Tissue Engineering Applications
In tissue engineering, the ability to manipulate scaffold design characteristics is important to achieve functional tissue regeneration. In this study, degradable polar hydrophobic ionic polyurethane (D-PHI) porous scaffolds were synthesized using a lysine-based divinyl oligomer (DVO). Optimization...
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Published in | Biomacromolecules Vol. 10; no. 10; pp. 2729 - 2739 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
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Washington, DC
American Chemical Society
12.10.2009
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Abstract | In tissue engineering, the ability to manipulate scaffold design characteristics is important to achieve functional tissue regeneration. In this study, degradable polar hydrophobic ionic polyurethane (D-PHI) porous scaffolds were synthesized using a lysine-based divinyl oligomer (DVO). Optimization studies on the DVO and D-PHI scaffold synthesis were conducted to maximize isocyanate and methacrylate monomer conversion, respectively. D-PHI scaffold properties were manipulated through the introduction of a lysine-based cross-linker. Specifically, increasing D-PHI cross-linker concentration resulted in an increase of the elastic modulus (0.5−21 MPa), a decrease of the elongation-at-yield (45−5%) and a reduction of scaffold swelling (170−100%). Based on a preliminary study with A10 vascular smooth muscle cells, D-PHI scaffolds demonstrated the ability to support cell adhesion and growth during 2 weeks of culture, suggesting their potential suitability for longer term vascular tissue engineering. The versatility of the D-PHI properties may allow for the tailoring of cell−material interaction and ultimately functional tissue regeneration. |
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AbstractList | In tissue engineering, the ability to manipulate scaffold design characteristics is important to achieve functional tissue regeneration. In this study, degradable polar hydrophobic ionic polyurethane (D-PHI) porous scaffolds were synthesized using a lysine-based divinyl oligomer (DVO). Optimization studies on the DVO and D-PHI scaffold synthesis were conducted to maximize isocyanate and methacrylate monomer conversion, respectively. D-PHI scaffold properties were manipulated through the introduction of a lysine-based cross-linker. Specifically, increasing D-PHI cross-linker concentration resulted in an increase of the elastic modulus (0.5−21 MPa), a decrease of the elongation-at-yield (45−5%) and a reduction of scaffold swelling (170−100%). Based on a preliminary study with A10 vascular smooth muscle cells, D-PHI scaffolds demonstrated the ability to support cell adhesion and growth during 2 weeks of culture, suggesting their potential suitability for longer term vascular tissue engineering. The versatility of the D-PHI properties may allow for the tailoring of cell−material interaction and ultimately functional tissue regeneration. In tissue engineering, the ability to manipulate scaffold design characteristics is important to achieve functional tissue regeneration. In this study, degradable polar hydrophobic ionic polyurethane (D-PHI) porous scaffolds were synthesized using a lysine-based divinyl oligomer (DVO). Optimization studies on the DVO and D-PHI scaffold synthesis were conducted to maximize isocyanate and methacrylate monomer conversion, respectively. D-PHI scaffold properties were manipulated through the introduction of a lysine-based cross-linker. Specifically, increasing D-PHI cross-linker concentration resulted in an increase of the elastic modulus (0.5-21 MPa), a decrease of the elongation-at-yield (45-5%) and a reduction of scaffold swelling (170-100%). Based on a preliminary study with A10 vascular smooth muscle cells, D-PHI scaffolds demonstrated the ability to support cell adhesion and growth during 2 weeks of culture, suggesting their potential suitability for longer term vascular tissue engineering. The versatility of the D-PHI properties may allow for the tailoring of cell-material interaction and ultimately functional tissue regeneration. |
Author | Labow, Rosalind S Sharifpoor, Soroor Santerre, J. Paul |
Author_xml | – sequence: 1 givenname: Soroor surname: Sharifpoor fullname: Sharifpoor, Soroor – sequence: 2 givenname: Rosalind S surname: Labow fullname: Labow, Rosalind S – sequence: 3 givenname: J. Paul surname: Santerre fullname: Santerre, J. Paul email: paul.santerre@dentistry.utoronto.ca |
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Keywords | Biological properties Cell proliferation Swelling Tissue engineering Mechanical properties Composition effect Experimental study Methyl methacrylate copolymer Urethane copolymer Porous material Polyaddition Macromer Crosslinked copolymer Methacrylic acid copolymer Morphology Preparation Polyurethane Cell adhesion Biomaterial Radical copolymerization Framework |
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SubjectTerms | Animals Applied sciences Biological and medical sciences Blood Vessels - cytology Cell Adhesion Cell Proliferation Cells, Cultured Exact sciences and technology Magnetic Resonance Spectroscopy Medical sciences Microscopy, Electron, Scanning Organic polymers Physicochemistry of polymers Polymers with particular properties Polyurethanes - chemical synthesis Preparation, kinetics, thermodynamics, mechanism and catalysts Rats Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Tissue Engineering |
Title | Synthesis and Characterization of Degradable Polar Hydrophobic Ionic Polyurethane Scaffolds for Vascular Tissue Engineering Applications |
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