Uncovering the Formation of Color Gradients for Glucose Colorimetric Assays on Microfluidic Paper-Based Analytical Devices by Mass Spectrometry Imaging

• Published in: Analytical chemistry (Washington) Vol. 90; no. 20; pp. 11949 - 11954
• Main Authors: de Freitas, Soraia V, de Souza, Fabrício R, Rodrigues Neto, Jorge C, Vasconcelos, Géssica A, Abdelnur, Patrícia V, Vaz, Boniek G, Henry, Charles S, Coltro, Wendell K. T
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 16.10.2018
• Subjects: Analytical chemistry; Assaying; Chemistry; Color; Colorimetry; Desorption; Glucose; Glucose oxidase; Horseradish peroxidase; Imaging; Iodides; Ionization; Lasers; Mass spectrometry; Mass spectroscopy; Mathematical analysis; Microfluidics; Peroxidase; Potassium; Potassium iodide; Potassium iodides; Reliability analysis; Reproducibility; Spatial distribution; Spectroscopy

This study describes the use of mass spectrometry imaging with matrix-assisted laser desorption/ionization (MALDI) and desorption electrospray ionization (DESI) to understand the color gradient generation commonly seen in microfluidic paper-based analytical devices (μPADs). The formation of color gr...