Effects of GluN2B-selective antagonists on delay and probability discounting in male rats: Modulation by delay/probability presentation order

• Published in: Experimental and clinical psychopharmacology Vol. 26; no. 6; p. 525
• Main Authors: Yates, Justin R, Prior, Nicholas A, Chitwood, Marissa R, Day, Haley A, Heidel, Jonah R, Hopkins, Sarah E, Muncie, Brittany T, Paradella-Bradley, Tatiana A, Sestito, Alexandra P, Vecchiola, Ashley N, Wells, Emily E
• Format: Journal Article
• Language: English
• Published: United States 01.12.2018
• Subjects: Animals; Choice Behavior - drug effects; Conditioning, Operant - drug effects; Delay Discounting - drug effects; Impulsive Behavior - drug effects; Male; Phenols - pharmacology; Piperidines - pharmacology; Probability; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Reinforcement (Psychology)

The contribution of the GluN2B subunit of the NMDA receptor to impulsivity has recently been examined. Ro 63-1908, a highly selective antagonist for the GluN2B, decreases impulsive choice. Because the order in which delays are presented modulates drug effects in discounting procedures, one goal of t...