Electrochemical Detection of Circulating Tumor Cells Based on DNA Generated Electrochemical Current and Rolling Circle Amplification

• Published in: Analytical chemistry (Washington) Vol. 91; no. 18; pp. 11614 - 11619
• Main Authors: Shen, Congcong, Liu, Shuping, Li, Xiaoqing, Yang, Minghui
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 17.09.2019
• Subjects: Amplification; Analytical chemistry; Antibodies; Aptamers; Blood; Breast cancer; Cell adhesion; Cell adhesion & migration; Cell adhesion molecules; Chemistry; Deoxyribonucleic acid; DNA; Electrochemical analysis; Electrochemistry; Metastases; Molybdate; Nanospheres; Peripheral blood; Tumor cells; Tumors

Circulating tumor cells (CTCs) are important indicators for tumor diagnosis and tumor metastasis. However, the extremely low levels of CTCs in peripheral blood challenges the precise detection of CTCs. Herein, we report DNA generated electrochemical current combined with rolling circle amplification...