Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells

• Published in: ACS chemical biology Vol. 11; no. 5; pp. 1305 - 1312
• Main Authors: Abrams, Rachel P, Carroll, William L, Woerpel, K. A
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 20.05.2016
• Subjects: Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Cell Death - drug effects; Cell Line; Cell Line, Tumor; Humans; Models, Molecular; Neoplasms - drug therapy; Neoplasms - metabolism; Oxidative Stress - drug effects; Peroxides - chemistry; Peroxides - pharmacology

A 1,2-dioxolane (FINO2) was identified as a lead compound from a screen of organic peroxides. FINO2 does not induce apoptosis, but instead initiates ferroptosis, an iron-dependent, oxidative cell death pathway. Few compounds are known to induce primarily ferroptosis. In contrast to the perceived ins...