Risk of Recurrence in Women With Bipolar Disorder During Pregnancy: Prospective Study of Mood Stabilizer Discontinuation

• Published in: The American journal of psychiatry Vol. 164; no. 12; pp. 1817 - 1824
• Main Authors: Viguera, Adele C., Whitfield, Theodore, Baldessarini, Ross J., Newport, D. Jeffrey, Stowe, Zachary, Reminick, Alison, Zurick, Amanda, Cohen, Lee S.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Psychiatric Association 01.12.2007
• Subjects: Adult; Adult and adolescent clinical studies; Anticonvulsants - adverse effects; Anticonvulsants - therapeutic use; Antidepressive Agents - adverse effects; Antidepressive Agents - therapeutic use; Antipsychotic Agents - adverse effects; Antipsychotic Agents - therapeutic use; Biological and medical sciences; Bipolar disorder; Bipolar Disorder - drug therapy; Bipolar Disorder - psychology; Bipolar disorders; Clinical medicine; Cohort Studies; Depressive Disorder - drug therapy; Depressive Disorder - psychology; Diseases of mother, fetus and pregnancy; Drug therapy; Drug Therapy, Combination; Female; Gynecology. Andrology. Obstetrics; Hospitals; Humans; Intellectual disabilities; Lithium Compounds - adverse effects; Lithium Compounds - therapeutic use; Medical disorders; Medical sciences; Mental institutions; Minority & ethnic groups; Mood disorders; Mortality; Neuropharmacology; Patient Dropouts - psychology; Pharmacology. Drug treatments; Pregnancy; Pregnancy Complications - drug therapy; Pregnancy Complications - psychology; Pregnancy. Fetus. Placenta; Prognosis; Prospective Studies; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Recurrence; Risk Factors; Substance Withdrawal Syndrome - epidemiology; Substance Withdrawal Syndrome - etiology; Substance Withdrawal Syndrome - psychology; Survival Analysis; Time Factors; Variables; Mood disorder; Human; Chemotherapy; Treatment; Pregnancy disorders; Follow up study; Mood stabilizer; Psychotropic; Risk factor; Female; Bipolar disorder; Woman

Objective: This study estimated the risk of recurrence of mood episodes among women with a history of bipolar disorder who continued or discontinued treatment with mood stabilizers during pregnancy. Method: In a prospective observational clinical cohort study, the authors determined recurrence risk...