Biosynthesis of 11-cis-retinoids and retinyl esters by bovine pigment epithelium membranes

• Published in: Biochemistry (Easton) Vol. 26; no. 24; pp. 7938 - 7945
• Main Authors: Fulton, Brian S, Rando, Robert R
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.12.1987
• Subjects: 11-cis-retinoids; Analytical, structural and metabolic biochemistry; Animals; Biological and medical sciences; Cattle; Cell Membrane - drug effects; Cell Membrane - metabolism; Fundamental and applied biological sciences. Psychology; Hydroxylamine; Hydroxylamines - pharmacology; Hydroxymercuribenzoates - pharmacology; Kinetics; Other biological molecules; pigment epithelium; Pigment Epithelium of Eye - metabolism; Rana; Retinaldehyde - biosynthesis; Retinoids - biosynthesis; Terpenes, steroids. Hormones; Tritium; Vitamin A - analogs & derivatives; Vitamin A - biosynthesis; Vertebrata; Mammalia; Isomerization; Ox; Membrane; Retina; Biosynthesis; Artiodactyla; Epithelium; Ungulata

Previously, we have shown that retina/pigment epithelium membranes from the amphibian can synthesize 11-cis-retinoids from added all-trans-retinol [Bernstein, P.S., Law, W.C., & Rando, R.R. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 1849-1853]. The activity was largely localized to the pigment epi...