Management of Pulmonary Arterial Hypertension with Sitaxentan Sodium

• Published in: Clinical Medicine Insights: Therapeutics Vol. 2011; no. 3; pp. 31 - 38
• Main Authors: Pulido, Tomas, Murillo, Carla, Ramírez-Neria, Paulina, Hurtado, Viridiana, de la Garza, Paola, Astorga, Sandra, Miranda, María Teresa, Sandoval, Julio
• Format: Journal Article Book Review
• Language: English
• Published: London, England Libertas Academica 01.01.2011; SAGE Publishing; SAGE Publications; Sage Publications Ltd
• Subjects: endothelin receptor antagonists; pulmonary arterial hypertension; sitaxentan

Pulmonary arterial hypertension (PAH) is a chronic and progressive disease with a poor prognosis if left untreated. Pathophysiological alterations in this disease lead to vasoconstriction, endothelial and smooth muscle cell proliferation, and in situ thrombosis. Endothelin-1 (one of the most potent...