Importance of Avidity for an Endogenous Drug Carrier: An Antibody Carrier for CpG Oligonucleotides

• Published in: Molecular pharmaceutics Vol. 7; no. 4; pp. 1338 - 1341
• Main Authors: Cheung, Roland, Cho, Moo
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 02.08.2010
• Subjects: Animals; Antibodies - administration & dosage; Antibodies - chemistry; Antibodies - immunology; Cell Line, Tumor; Drug Carriers - administration & dosage; Drug Carriers - chemistry; Enzyme-Linked Immunosorbent Assay; Mice; Mice, Inbred BALB C; Neoplasms - drug therapy; Nitrobenzenes - chemistry; Oligodeoxyribonucleotides - administration & dosage; Oligodeoxyribonucleotides - chemistry; Oligodeoxyribonucleotides - immunology; avidity; Endogenous carriers; CpG ODN; pharmacokinetic and pharmacodynamic; immune complexes; solid tumors

In animal models, successful anticancer monotherapy with CpG oligodeoxynucleotide (ODN) has been limited to the intratumoral and peritumoral routes of administration. To overcome this limitation, we developed a delivery system utilizing an endogenous antibody as a carrier for CpG ODNs. When a 1:1 co...