Disease Tolerance as an Inherent Component of Immunity

• Published in: Annual review of immunology Vol. 37; no. 1; pp. 405 - 437
• Main Authors: Martins, Rui, Carlos, Ana Rita, Braza, Faouzi, Thompson, Jessica A, Bastos-Amador, Patricia, Ramos, Susana, Soares, Miguel P
• Format: Journal Article
• Language: English
• Published: United States Annual Reviews 26.04.2019
• Subjects: damage; disease tolerance; immunoregulation; infection; metabolism; microbiota; nutritional immunity; stress; tissue damage control; microbiota; damage; stress; infection; nutritional immunity; disease tolerance; immunoregulation; metabolism; tissue damage control

Pathogenic organisms exert a negative impact on host health, revealed by the clinical signs of infectious diseases. Immunity limits the severity of infectious diseases through resistance mechanisms that sense and target pathogens for containment, killing, or expulsion. These resistance mechanisms ar...