Structure of Condensed Phase Peptides: Insights from Vibrational Circular Dichroism and Raman Optical Activity Techniques

• Published in: Chemical reviews Vol. 120; no. 7; pp. 3381 - 3419
• Main Author: Keiderling, Timothy A
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 08.04.2020
• Subjects: Chirality; Coupling (molecular); Diagnostic software; Diagnostic systems; Dichroism; Environmental changes; Molecular structure; Optical activity; Peptides; Proteins; Sensitivity; Spectral methods; Structural members

Peptides and proteins are naturally chiral molecular systems so that sensing their structure and conformation with chirality-based spectral methods is an obvious and long-used diagnostic application. Extending chiroptical techniques to measurement of vibrational transitions, in the form of vibration...