MGF360-9L Is a Major Virulence Factor Associated with the African Swine Fever Virus by Antagonizing the JAK/STAT Signaling Pathway

• Published in: mBio Vol. 13; no. 1; p. e0233021
• Main Authors: Zhang, Keshan, Yang, Bo, Shen, Chaochao, Zhang, Ting, Hao, Yu, Zhang, Dajun, Liu, Huanan, Shi, Xijuan, Li, Guoli, Yang, Jinke, Li, Dan, Zhu, Zixiang, Tian, Hong, Yang, Fan, Ru, Yi, Cao, Wei Jun, Guo, Jianhong, He, Jijun, Zheng, Haixue, Liu, Xiangtao
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 22.02.2022
• Subjects: African Swine Fever; African Swine Fever Virus - genetics; Animals; ASFV; Host-Microbial Interactions; immune escape; JAK/STAT signal pathway; Janus Kinases - metabolism; Macrophages; MGF360-9L; Research Article; Signal Transduction; STAT Transcription Factors - metabolism; STAT1/2; Swine; Viral Proteins - genetics; virulence factor; Virulence Factors - genetics; JAK/STAT signal pathway; STAT1/2; in vitro; immune escape; in vivo; virulence factor; ASFV; MGF360-9L

African swine fever—an acute, febrile, hemorrhagic, highly contacting, and highly lethal disease caused by African swine fever virus (ASFV)—jeopardizes the global pig industry. Understanding the mechanism ASFV employs to evade host defense during infection is essential for developing targeted drugs...