Anti-inflammatory and Protective Properties of Daphnetin in Endotoxin-Induced Lung Injury

• Published in: Journal of agricultural and food chemistry Vol. 62; no. 51; pp. 12315 - 12325
• Main Authors: Yu, Wen-wen, Lu, Zhe, Zhang, Hang, Kang, Yan-hua, Mao, Yun, Wang, Huan-huan, Ge, Wei-hong, Shi, Li-yun
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 24.12.2014; American Chemical Society, Books and Journals Division
• Subjects: Animals; anti-inflammatory activity; Anti-Inflammatory Agents - administration & dosage; bronchitis; coumarin; Endotoxins - toxicity; epithelial cells; Humans; immunopathology; inflammation; lipopolysaccharides; Lung Injury - chemically induced; Lung Injury - genetics; Lung Injury - immunology; Lung Injury - prevention & control; macrophage activation; macrophages; Macrophages - drug effects; Macrophages - immunology; Mice; Mice, Inbred C57BL; NF-kappa B - genetics; NF-kappa B - immunology; pathogenesis; Protective Agents - administration & dosage; protective effect; transcription factor NF-kappa B; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - immunology; ubiquitination; Umbelliferones - administration & dosage; lung injury; inflammation; ubiquitination

Uncontrolled inflammatory responses cause tissue injury and severe immunopathology. Pharmacological interference of intracellular pro-inflammatory signaling may confer a therapeutic benefit under these conditions. Daphnetin, a natural coumarin derivative, has been used to treat inflammatory diseases...