Two-Stage Experimental Design for Dose–Response Modeling in Toxicology Studies

• Published in: ACS sustainable chemistry & engineering Vol. 1; no. 9; pp. 1119 - 1128
• Main Authors: Wang, Kai, Yang, Feng, Porter, Dale W, Wu, Nianqiang
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 03.09.2013
• Subjects: algorithms; animals; artificial intelligence; dose response; experimental design; statistical analysis; toxicology; uncertainty; variance; Dose−response; Nanomaterials; Toxicology; Design of experiments; Benchmark dose; Dose–response

The efficient design of experiments (i.e., selection of experimental doses and allocation of animals) is important to establishing dose–response relationships in toxicology studies. The proposed procedure for design of experiments is distinct from those in the literature because it is able to adequa...