The Neuroendocrine Protein 7B2 Is Intrinsically Disordered

• Published in: Biochemistry (Easton) Vol. 51; no. 38; pp. 7456 - 7464
• Main Authors: Dasgupta, Indrani, Sanglas, Laura, Enghild, Jan J, Lindberg, Iris
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 25.09.2012
• Subjects: Chromatography, Gel; Circular Dichroism; Humans; Neuroendocrine Secretory Protein 7B2 - chemistry; Neuroendocrine Secretory Protein 7B2 - isolation & purification; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary; Spectrometry, Fluorescence; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

The small neuroendocrine protein 7B2 has been shown to be required for the productive maturation of proprotein convertase 2 (proPC2) to an active enzyme form; this action is accomplished via its ability to block aggregation of proPC2 into nonactivatable forms. Recent data show that 7B2 can also act...