Copper-Mediated Fluorination of Aryl Iodides

• Published in: Journal of the American Chemical Society Vol. 134; no. 26; pp. 10795 - 10798
• Main Authors: Fier, Patrick S., Hartwig, John F.
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 04.07.2012; Amer Chemical Soc
• Subjects: agrochemicals; aromatic hydrocarbons; Benzene Derivatives - chemistry; Chemistry; Chemistry, Multidisciplinary; Copper; drugs; fluorides; Fluorides - chemistry; Halogenation; Hydrocarbons, Fluorinated - chemical synthesis; Iodides; Physical Sciences; Science & Technology; Silver Compounds; ULLMANN CONDENSATION; HALIDES; REAGENT; PALLADIUM; MODELS; MECHANISMS; DERIVATIVES; BROMIDES; SALTS; FLUORIDE

The synthesis of aryl fluorides has been studied intensively because of the importance of aryl fluorides in pharmaceuticals, agrochemicals, and materials. The stability, reactivity, and biological properties of aryl fluorides can be distinct from those of the corresponding arenes. Methods for the sy...