Oxidation of the Cyanobacterial Hepatotoxin Microcystin-LR by Chlorine Dioxide: Reaction Kinetics, Characterization, and Toxicity of Reaction Products
Cyanobacteria are known producers of cytotoxins, hepatotoxins, and neurotoxins. The main toxins are microcystins, cyclic heptapeptide hepatotoxins, produced by strains of several cyanobacterial genera frequently found in eutrophied freshwaters. Due to the acute and chronic toxicity of microcystins,...
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Published in | Environmental science & technology Vol. 38; no. 22; pp. 6025 - 6031 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Washington, DC
American Chemical Society
15.11.2004
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Abstract | Cyanobacteria are known producers of cytotoxins, hepatotoxins, and neurotoxins. The main toxins are microcystins, cyclic heptapeptide hepatotoxins, produced by strains of several cyanobacterial genera frequently found in eutrophied freshwaters. Due to the acute and chronic toxicity of microcystins, successful removal of these toxins in drinking water treatment processes is of increasing concern. In the present work the kinetics of microcystin-LR (MC-LR) oxidation by chlorine dioxide (ClO2) was studied with UV-spectrometry and high performance liquid chromatography (HPLC). Characterization of reaction products was performed with mass spectrometric (MS) analysis, while the toxicity of reaction products was tested with a protein phosphatase inhibition assay (PPIA). The main reaction products formed, dihydroxy isomers of MC-LR as identified by MS, were nontoxic according to the PPIA. The overall rate constant k for the reaction between MC-LR and ClO2 at 293 K and pH 5.65 was modest, k = 1.24 M-1 s-1, suggesting that ClO2 is not a suitable oxidant for the degradation of microcystins in drinking water treatment processes. |
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AbstractList | Cyanobacteria are known producers of cytotoxins, hepatotoxins, and neurotoxins. The main toxins are microcystins, cyclic heptapepticle hepatotoxins, produced by strains of several cyanobacterial genera frequently found in eutrophied freshwaters. Due to the acute and chronic toxicity of microcystins, successful removal of these toxins in drinking water treatment processes is of increasing concern. In the present work the kinetics of microcystin-LR (MC-LR) oxidation by chlorine dioxide (CI02) was studied with UV-spectrometry and high performance liquid chromatography (HPLC). Characterization of reaction products was performed with mass spectrometric (IMS) analysis, while the toxicity of reaction products was tested with a protein phosphatase inhibition assay (PPIA). The main reaction products formed, dihydroxy isomers of MC-LR as identified by IMS, were nontoxic according to the PPIA. The overall rate constant k for the reaction between MC-LR and C102 at 293 K and pH 5.65 was modest k = 1.24 M-1 s-1, suggesting that C102 is not a suitable oxidant for the degradation of microcystins in drinking water treatment processes. [PUBLICATION ABSTRACT] Cyanobacteria are known producers of cytotoxins, hepatotoxins, and neurotoxins. The main toxins are microcystins, cyclic heptapeptide hepatotoxins, produced by strains of several cyanobacterial genera frequently found in eutrophied freshwaters. Due to the acute and chronic toxicity of microcystins, successful removal of these toxins in drinking water treatment processes is of increasing concern. In the present work the kinetics of microcystin-LR (MC-LR) oxidation by chlorine dioxide (ClO sub(2)) was studied with UV-spectrometry and high performance liquid chromatography (HPLC). Characterization of reaction products was performed with mass spectrometric (MS) analysis, while the toxicity of reaction products was tested with a protein phosphatase inhibition assay (PPIA). The main reaction products formed, dihydroxy isomers of MC-LR as identified by MS, were nontoxic according to the PPIA. The overall rate constant k for the reaction between MC-LR and ClO sub(2) at 293 K and pH 5.65 was modest, k = 1.24 M super(-1) s super(-1), suggesting that ClO sub(2) is not a suitable oxidant for the degradation of microcystins in drinking water treatment processes. Cyanobacteria are known producers of cytotoxins, hepatotoxins, and neurotoxins. The main toxins are microcystins, cyclic heptapeptide hepatotoxins, produced by strains of several cyanobacterial genera frequently found in eutrophied freshwaters. Due to the acute and chronic toxicity of microcystins, successful removal of these toxins in drinking water treatment processes is of increasing concern. In the present work the kinetics of microcystin-LR (MC-LR) oxidation by chlorine dioxide (ClO2) was studied with UV-spectrometry and high performance liquid chromatography (HPLC). Characterization of reaction products was performed with mass spectrometric (MS) analysis, while the toxicity of reaction products was tested with a protein phosphatase inhibition assay (PPIA). The main reaction products formed, dihydroxy isomers of MC-LR as identified by MS, were nontoxic according to the PPIA. The overall rate constant k for the reaction between MC-LR and ClO2 at 293 K and pH 5.65 was modest, k = 1.24 M(-1) s(-1), suggesting that ClO2 is not a suitable oxidant for the degradation of microcystins in drinking water treatment processes. |
Author | Backlund, Peter H Kull, Tomas P. J Meriluoto, Jussi A. O Karlsson, Krister M |
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Keywords | Chlorination Cyclic peptides Phosphoprotein phosphatase Toxicity Phosphoric monoester hydrolases HPLC chromatography Esterases Cyanobacteria Bacteria Oxidation Drinking water treatment Bioassay Enzyme Reaction product Enzyme inhibitor Disinfection Chlorine dioxide Ultraviolet spectrometry Toxin Microbial origin Polypeptide Bloom Hydrolases Kinetics Mass spectrometry |
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SubjectTerms | Air. Soil. Water. Waste. Feeding Applied sciences Bacteria Biological and medical sciences Chlorine Chlorine Compounds - chemistry Chromatography, High Pressure Liquid Cyanobacteria Cyanobacteria - chemistry Drinking water Drinking water and swimming-pool water. Desalination Environment. Living conditions Enzyme Inhibitors Eutrophication Exact sciences and technology Kinetics Mass Spectrometry Medical sciences Microcystins Oxidation Oxidation-Reduction Oxides - chemistry Peptides, Cyclic - chemistry Phosphoric Monoester Hydrolases - antagonists & inhibitors Pollution Public health. Hygiene Public health. Hygiene-occupational medicine Reaction kinetics Toxicity Toxins Water Microbiology Water Pollutants, Chemical - analysis Water treatment Water treatment and pollution |
Title | Oxidation of the Cyanobacterial Hepatotoxin Microcystin-LR by Chlorine Dioxide: Reaction Kinetics, Characterization, and Toxicity of Reaction Products |
URI | http://dx.doi.org/10.1021/es0400032 https://api.istex.fr/ark:/67375/TPS-TZB5Z8HV-J/fulltext.pdf https://www.ncbi.nlm.nih.gov/pubmed/15573602 https://www.proquest.com/docview/230150175/abstract/ https://search.proquest.com/docview/19928857 |
Volume | 38 |
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