Precision and Accuracy in the Quantitative Analysis of Biological Samples by Accelerator Mass Spectrometry: Application in Microdose Absolute Bioavailability Studies

• Published in: Analytical chemistry (Washington) Vol. 83; no. 14; pp. 5607 - 5616
• Main Authors: Gao, Lan, Li, Jing, Kasserra, Claudia, Song, Qi, Arjomand, Ali, Hesk, David, Chowdhury, Swapan K
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 15.07.2011
• Subjects: Accuracy; Administration, Oral; Adult; Analytical chemistry; Antiviral Agents - administration & dosage; Antiviral Agents - blood; Bioavailability; Biological analysis; Biological samples; Calibration; Chemical compounds; Chemistry; Chromatographic methods and physical methods associated with chromatography; Chromatography, Liquid; Correlation coefficient; Dipeptides - administration & dosage; Dipeptides - blood; Exact sciences and technology; Humans; Injections, Intravenous; Male; Mass spectrometry; Middle Aged; Other chromatographic methods; Pharmacokinetics; Plasma; Regression analysis; Reproducibility of Results; Sensitivity and Specificity; Spectrometric and optical methods; Statistical analysis; Sulfones - administration & dosage; Sulfones - blood; Tandem Mass Spectrometry - methods; Veterinary medicine; Young Adult; Isotopic analysis; Plasma; Chemical analysis; Time; Calibration standards; Accuracy; Quality; Regression function; Sampling; Quantitative analysis; Correlation coefficient; Human; Drug; Biochemical analysis; Sample; Liquid chromatography; Foodstuff; Bioavailability; Concentration; Method; Chemical ionization; Biological compound; Mass spectrometry MS/MS; Quality control; Negative ion; Limit; Pharmacokinetics; Application; Mass spectrometry
• ISSN: 0003-2700; 1520-6882; 1520-6882
• DOI: 10.1021/ac2006284

Determination of the pharmacokinetics and absolute bioavailability of an experimental compound, SCH 900518, following a 89.7 nCi (100 μg) intravenous (iv) dose of 14C-SCH 900518 2 h post 200 mg oral administration of nonradiolabeled SCH 900518 to six healthy male subjects has been described. The pla...