Discrimination of Breast Cancer by Measuring Prostate-Specific Antigen Levels in Women's Serum

• Published in: Analytical chemistry (Washington) Vol. 83; no. 13; pp. 5324 - 5328
• Main Authors: Chang, Ying-Feng, Hung, Shuo-Hui, Lee, Yi-Jang, Chen, Ran-Chou, Su, Li-Chen, Lai, Chao-Sung, Chou, Chien
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.07.2011
• Subjects: Analytical chemistry; Antigens; Biological and medical sciences; Biomarkers; Biosensors; Biotechnology; Breast cancer; Breast Neoplasms - blood; Breast Neoplasms - diagnosis; Case-Control Studies; Chemistry; Correlation coefficient; Electrochemical methods; Exact sciences and technology; Female; Fluorescence; Fundamental and applied biological sciences. Psychology; Humans; Immunoassay; Methods. Procedures. Technologies; Miscellaneous; Prostate-Specific Antigen - blood; Spectrometric and optical methods; Surface Plasmon Resonance; Various methods and equipments; Performance evaluation; Phosphates; Fold; Chemical analysis; Fluorescence; Biological marker; Fluorescence spectrometry; Immunological method; Prostate specific antigen; Signal; Serum; Correlation coefficient; Sample; Use; Ultratrace compound; Breast cancer; Concentration; Chemical sensor; Surface plasmon; Potentiometry; Buffer solution; Sensitivity; Biosensor; Detection; Saline solution

Prostate-specific antigen (PSA) has been reported to be a potential biomarker of breast cancer. Serum PSA of normal women is around 1 pg/mL, which is usually undetectable by current assay methods; thus an ultrasensitive measurement of PSA expression in women's serum is necessary to distinguish...