Aggregation-Induced Emission: A Trailblazing Journey to the Field of Biomedicine

The emergence of the aggregation-induced emission (AIE) concept significantly changes the cognition of the scientific community toward classic photophysical phenomena. More importantly, the AIE phenomenon has brought huge opportunities for the analysis of bioactive species, the monitoring of complic...

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Published inACS applied bio materials Vol. 1; no. 6; pp. 1768 - 1786
Main Authors Zhu, Chunlei, Kwok, Ryan T. K, Lam, Jacky W. Y, Tang, Ben Zhong
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 17.12.2018
Subjects
aggregation-induced emission
biosensing
cell imaging
theranostics
in vivo bioimaging
biomedical applications
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Abstract The emergence of the aggregation-induced emission (AIE) concept significantly changes the cognition of the scientific community toward classic photophysical phenomena. More importantly, the AIE phenomenon has brought huge opportunities for the analysis of bioactive species, the monitoring of complicated biological processes, and the elucidation of key physiological and pathological behaviors. As a class of promising luminescent materials, AIE luminogens (AIEgens) are weakly or non-emissive in the form of isolated molecular species but emit particularly strong fluorescence in the aggregated and solid states. Motivated by the prominent advantages such as high brightness, large Stokes shift, excellent photostability, and good biocompatibility, AIEgen-based bioprobes have been widely explored in the field of biomedicine. This review aims to provide a systematic summary of the developmental history and an in-depth perspective of the current landscape of AIE in the biomedical field, with an emphasis on the discussions of major working principles. The milestones of the historical development of AIE in the biomedical field are first reviewed. A total of four major research directions are then extracted, including biomacromolecule sensing (at the molecular level), in vitro cell imaging (at the cellular level), in vivo imaging (at the animal level), and cancer theranostics (at the cellular and animal levels), together with clear-cut tables showing comprehensive cases for further study. Lastly, this review is concluded by the discussions of several perspectives on future directions. It is believed that AIEgen-based bioprobes will play vital roles in the exploration of mysterious life processes by integration with various cutting-edge modalities and techniques with an ultimate goal of addressing more healthcare issues.
AbstractList The emergence of the aggregation-induced emission (AIE) concept significantly changes the cognition of the scientific community toward classic photophysical phenomena. More importantly, the AIE phenomenon has brought huge opportunities for the analysis of bioactive species, the monitoring of complicated biological processes, and the elucidation of key physiological and pathological behaviors. As a class of promising luminescent materials, AIE luminogens (AIEgens) are weakly or non-emissive in the form of isolated molecular species but emit particularly strong fluorescence in the aggregated and solid states. Motivated by the prominent advantages such as high brightness, large Stokes shift, excellent photostability, and good biocompatibility, AIEgen-based bioprobes have been widely explored in the field of biomedicine. This review aims to provide a systematic summary of the developmental history and an in-depth perspective of the current landscape of AIE in the biomedical field, with an emphasis on the discussions of major working principles. The milestones of the historical development of AIE in the biomedical field are first reviewed. A total of four major research directions are then extracted, including biomacromolecule sensing (at the molecular level), in vitro cell imaging (at the cellular level), in vivo imaging (at the animal level), and cancer theranostics (at the cellular and animal levels), together with clear-cut tables showing comprehensive cases for further study. Lastly, this review is concluded by the discussions of several perspectives on future directions. It is believed that AIEgen-based bioprobes will play vital roles in the exploration of mysterious life processes by integration with various cutting-edge modalities and techniques with an ultimate goal of addressing more healthcare issues.
The emergence of the aggregation-induced emission (AIE) concept significantly changes the cognition of the scientific community toward classic photophysical phenomena. More importantly, the AIE phenomenon has brought huge opportunities for the analysis of bioactive species, the monitoring of complicated biological processes, and the elucidation of key physiological and pathological behaviors. As a class of promising luminescent materials, AIE luminogens (AIEgens) are weakly or non-emissive in the form of isolated molecular species but emit particularly strong fluorescence in the aggregated and solid states. Motivated by the prominent advantages such as high brightness, large Stokes shift, excellent photostability, and good biocompatibility, AIEgen-based bioprobes have been widely explored in the field of biomedicine. This review aims to provide a systematic summary of the developmental history and an in-depth perspective of the current landscape of AIE in the biomedical field, with an emphasis on the discussions of major working principles. The milestones of the historical development of AIE in the biomedical field are first reviewed. A total of four major research directions are then extracted, including biomacromolecule sensing (at the molecular level), in vitro cell imaging (at the cellular level), in vivo imaging (at the animal level), and cancer theranostics (at the cellular and animal levels), together with clear-cut tables showing comprehensive cases for further study. Lastly, this review is concluded by the discussions of several perspectives on future directions. It is believed that AIEgen-based bioprobes will play vital roles in the exploration of mysterious life processes by integration with various cutting-edge modalities and techniques with an ultimate goal of addressing more healthcare issues.The emergence of the aggregation-induced emission (AIE) concept significantly changes the cognition of the scientific community toward classic photophysical phenomena. More importantly, the AIE phenomenon has brought huge opportunities for the analysis of bioactive species, the monitoring of complicated biological processes, and the elucidation of key physiological and pathological behaviors. As a class of promising luminescent materials, AIE luminogens (AIEgens) are weakly or non-emissive in the form of isolated molecular species but emit particularly strong fluorescence in the aggregated and solid states. Motivated by the prominent advantages such as high brightness, large Stokes shift, excellent photostability, and good biocompatibility, AIEgen-based bioprobes have been widely explored in the field of biomedicine. This review aims to provide a systematic summary of the developmental history and an in-depth perspective of the current landscape of AIE in the biomedical field, with an emphasis on the discussions of major working principles. The milestones of the historical development of AIE in the biomedical field are first reviewed. A total of four major research directions are then extracted, including biomacromolecule sensing (at the molecular level), in vitro cell imaging (at the cellular level), in vivo imaging (at the animal level), and cancer theranostics (at the cellular and animal levels), together with clear-cut tables showing comprehensive cases for further study. Lastly, this review is concluded by the discussions of several perspectives on future directions. It is believed that AIEgen-based bioprobes will play vital roles in the exploration of mysterious life processes by integration with various cutting-edge modalities and techniques with an ultimate goal of addressing more healthcare issues.
Author Lam, Jacky W. Y
Zhu, Chunlei
Kwok, Ryan T. K
Tang, Ben Zhong
AuthorAffiliation HKUST-Shenzhen Research Institute
South China University of Technology
Centre for Aggregation-Induced Emission, SCUT-HKUST Joint Research Institute, State Key Laboratory of Luminescent Materials and Devices
Department of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, Department of Chemical and Biological Engineering and Division of Life Science
Key Laboratory of Functional Polymer Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry
AuthorAffiliation_xml – name: South China University of Technology
– name: Department of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, Department of Chemical and Biological Engineering and Division of Life Science
– name: Centre for Aggregation-Induced Emission, SCUT-HKUST Joint Research Institute, State Key Laboratory of Luminescent Materials and Devices
– name: Key Laboratory of Functional Polymer Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry
– name: HKUST-Shenzhen Research Institute
Author_xml – sequence: 1
  givenname: Chunlei
  orcidid: 0000-0003-2477-306X
  surname: Zhu
  fullname: Zhu, Chunlei
  organization: Key Laboratory of Functional Polymer Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry
– sequence: 2
  givenname: Ryan T. K
  orcidid: 0000-0002-6866-3877
  surname: Kwok
  fullname: Kwok, Ryan T. K
  organization: Department of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, Department of Chemical and Biological Engineering and Division of Life Science
– sequence: 3
  givenname: Jacky W. Y
  surname: Lam
  fullname: Lam, Jacky W. Y
  organization: Department of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, Department of Chemical and Biological Engineering and Division of Life Science
– sequence: 4
  givenname: Ben Zhong
  orcidid: 0000-0002-0293-964X
  surname: Tang
  fullname: Tang, Ben Zhong
  email: tangbenz@ust.hk
  organization: HKUST-Shenzhen Research Institute
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34996278$$D View this record in MEDLINE/PubMed
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Snippet The emergence of the aggregation-induced emission (AIE) concept significantly changes the cognition of the scientific community toward classic photophysical...
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Title Aggregation-Induced Emission: A Trailblazing Journey to the Field of Biomedicine
URI http://dx.doi.org/10.1021/acsabm.8b00600
https://www.ncbi.nlm.nih.gov/pubmed/34996278
https://www.proquest.com/docview/2618225724
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