Formulation and Characterization of Nanoemulsion Intranasal Adjuvants: Effects of Surfactant Composition on Mucoadhesion and Immunogenicity

• Published in: Molecular pharmaceutics Vol. 11; no. 2; pp. 531 - 544
• Main Authors: Wong, Pamela T, Wang, Su He, Ciotti, Susan, Makidon, Paul E, Smith, Douglas M, Fan, Yongyi, Schuler, Charles F, Baker, James R
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 03.02.2014
• Subjects: Adjuvants, Immunologic - chemistry; Adjuvants, Immunologic - pharmacology; Administration, Intranasal; Animals; Cell Adhesion - drug effects; Cell Line; Chemistry, Pharmaceutical; Emulsions - chemistry; Emulsions - pharmacology; Female; Humans; Immunogenetic Phenomena; Mice; Microscopy, Electron, Transmission; Nanotechnology; Nasal Mucosa - drug effects; Surface-Active Agents - chemistry; Surface-Active Agents - pharmacology; intranasal vaccine; oil-in-water emulsion; mucoadhesion; nanoemulsion; adjuvant

The development of effective intranasal vaccines is of great interest due to their potential to induce both mucosal and systemic immunity. Here we produced oil-in-water nanoemulsion (NE) formulations containing various cationic and nonionic surfactants for use as adjuvants for the intranasal deliver...