Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia - Dounay, Amy B; Anderson, Marie; Bechle, Bruce M; Campbell, Brian M; Claffey, Michelle M; Evdokimov, Artem; Evrard, Edelweiss; Fonseca, Kari R; Gan, Xinmin; Ghosh, Somraj; Hayward, Matthew M; Horner, Weldon; et al. (ACS medicinal chemistry letters, 2012)
Keywords: Chemistry, Medicinal; Letter; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Science & Technology; hydroxamic acid; KAT II; kynurenine aminotransferase; kynurenic acid; ACID; COVALENT; CRYSTAL-STRUCTURE; CEREBROSPINAL-FLUID; EXTRACELLULAR GLUTAMATE; STRATEGIES; ALIGNMENT; PATHWAY; ELEVATED LEVELS