Optimization of Antitumor Modulators of Pre-mRNA Splicing - Lagisetti, Chandraiah; Palacios, Gustavo; Goronga, Tinopiwa; Freeman, Burgess; Caufield, William; Webb, Thomas R (Journal of medicinal chemistry, 2013)
Keywords: Animals; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Cell Proliferation - drug effects; Chemistry, Medicinal; Cyclohexylamines - chemical synthesis; Cyclohexylamines - chemistry; Cyclohexylamines - pharmacology; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Life Sciences & Biomedicine; Male; Mice; Mice, SCID; Molecular Structure; Neoplasms, Experimental - drug therapy; Neoplasms, Experimental - genetics; Pharmacology & Pharmacy; RNA Splicing - drug effects; Science & Technology; Spiro Compounds - chemical synthesis; Spiro Compounds - chemistry; Spiro Compounds - pharmacology; Spliceosomes - drug effects; Spliceosomes - genetics; Spliceosomes - metabolism; Structure-Activity Relationship; Tumor Cells, Cultured; TARGET; AGENT; COMBINATIONS; FR901464; METABOLISM; SF3B; SPLICEOSOME; SUBSTANCES; MUTATIONS