High-Level Cefixime- and Ceftriaxone-Resistant Neisseria gonorrhoeae in France: Novel penA Mosaic Allele in a Successful International Clone Causes Treatment Failure

• Published in: Antimicrobial Agents and Chemotherapy Vol. 56; no. 3; pp. 1273 - 1280
• Main Authors: Unemo, Magnus, Golparian, Daniel, Nicholas, Robert, Ohnishi, Makoto, Gallay, Anne, Sednaoui, Patrice
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.03.2012
• Subjects: Alleles; Amino Acid Sequence; Anti-Bacterial Agents; Anti-Bacterial Agents - administration & dosage; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacterial diseases; Bacterial diseases of the genital system; Biological and medical sciences; Biomarkers - analysis; Cefixime; Cefixime - administration & dosage; Ceftriaxone; Ceftriaxone - administration & dosage; Cephalosporin Resistance; Cephalosporin Resistance - drug effects; Cephalosporin Resistance - genetics; Epidemiology. Vaccinations; France; General aspects; Gonorrhea; Gonorrhea - drug therapy; Gonorrhea - microbiology; Human bacterial diseases; Humans; Infectious diseases; Male; Mechanisms of Resistance; Medical sciences; Microbial Sensitivity Tests; Middle Aged; Molecular Sequence Data; Mosaicism; Multilocus Sequence Typing; Neisseria gonorrhoeae; Neisseria gonorrhoeae - drug effects; Neisseria gonorrhoeae - genetics; Neisseria gonorrhoeae - isolation & purification; Pharmacology. Drug treatments; Population Surveillance; Porins - analysis; Porins - genetics; Treatment Failure; France; Europe; Clonality; β-Lactams; Neisseriaceae; Ceftriaxone; Infection; Resistance; Cephalosporin derivatives; Allele; Antibiotic; Sexually transmitted disease; Gonococcal infection; Neisseria gonorrhoeae; Treatment; Bacteriosis; Bacteria; Micrococcales; Genetics; Mosaicism; Antibacterial agent; Cefixime; Failure; Clone; International

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