Decreased Conflict- and Error-Related Activity in the Anterior Cingulate Cortex in Subjects With Schizophrenia

• Published in: The American journal of psychiatry Vol. 162; no. 10; pp. 1833 - 1839
• Main Authors: Kerns, John G., Cohen, Jonathan D., MacDonald, Angus W., Johnson, Melissa K., Stenger, V. Andrew, Aizenstein, Howard, Carter, Cameron S.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Psychiatric Publishing 01.10.2005; American Psychiatric Association
• Subjects: Adult; Adult and adolescent clinical studies; Behavior; Biological and medical sciences; Cognition Disorders - diagnosis; Cognition Disorders - physiopathology; Cognitive therapy; Conflict (Psychology); Evoked Potentials - physiology; Female; Gyrus Cinguli - physiopathology; Humans; Magnetic Resonance Imaging - statistics & numerical data; Male; Medical sciences; Neurology; Neuropsychological Tests - statistics & numerical data; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychomotor Performance - physiology; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - physiopathology; Schizophrenic Psychology; Psychosis; Human; Cingulate cortex; Conflict; Central nervous system; Schizophrenia; Error; Cognition; Encephalon

OBJECTIVE: People with schizophrenia have exhibited reduced functional activity in the anterior cingulate cortex during the performance of many types of cognitive tasks and during the commission of errors. According to conflict theory, the anterior cingulate cortex is involved in the monitoring of r...