A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment - Cai, Qian; Sun, Haiying; Peng, Yuefeng; Lu, Jianfeng; Nikolovska-Coleska, Zaneta; McEachern, Donna; Liu, Liu; Qiu, Su; Yang, Chao-Yie; Miller, Rebecca; Yi, Han; Zhang, Tao; et al. (Journal of medicinal chemistry, 2011)
Keywords: Administration, Oral; Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Apoptosis - drug effects; Area Under Curve; Azocines - pharmacokinetics; Azocines - pharmacology; Azocines - therapeutic use; Benzhydryl Compounds - pharmacokinetics; Benzhydryl Compounds - pharmacology; Benzhydryl Compounds - therapeutic use; Biological Availability; Cell Line, Tumor; Chemistry, Medicinal; Humans; Inhibitor of Apoptosis Proteins - antagonists & inhibitors; Life Sciences & Biomedicine; Models, Molecular; Neoplasms - drug therapy; Pharmacology & Pharmacy; Science & Technology; SMALL-MOLECULE MIMETICS; X-LINKED INHIBITOR; MITOCHONDRIA-DERIVED ACTIVATOR; XIAP BIR3 DOMAIN; STRUCTURAL BASIS; ALPHA-DEPENDENT APOPTOSIS; CASPASE INHIBITION; CONSTRAINED SMAC MIMETICS; NF-KAPPA-B; STRUCTURE-BASED DESIGN