Comparative postantibacterial activities of pefloxacin, ciprofloxacin, and ofloxacin against intracellular multiplication of Legionella pneumophila serogroup 1
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Published in | Antimicrobial Agents and Chemotherapy Vol. 34; no. 9; pp. 1733 - 1738 |
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Format | Journal Article |
Language | English |
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American Society for Microbiology
01.09.1990
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AbstractList | The inhibitory and postantibacterial activities of pefloxacin, ciprofloxacin, and ofloxacin against virulent Legionella pneumophila serogroup 1 were evaluated in cell-free and cellular models. In the absence of macrophages (with the tissue culture medium alone), bacterial numbers remained unchanged at 24 h in the presence of 0.1 microgram of pefloxacin, ciprofloxacin, or ofloxacin per ml and 1.0 microgram of pefloxacin per ml, whereas they were reduced in the presence of 1.0 microgram of ciprofloxacin or ofloxacin per ml. Experiments to evaluate the postantibacterial effects of these drugs were therefore performed with concentrations of 0.1 microgram/ml. In the cell-free model, brief exposure (1 h) of bacteria to each antimicrobial agent resulted in a transient decrease in numbers followed by logarithmic growth. In the cellular model, all three drugs (at 0.1 and 1.0 microgram/ml) inhibited the intracellular multiplication of L. pneumophila. The intracellular postantibacterial effects of 0.1 microgram of pefloxacin, ciprofloxacin, and ofloxacin per ml, which were left in contact with L. pneumophila-infected human macrophages for 24 h, were evaluated at various times after removal of the drugs. Pefloxacin was found to exhibit a significant inhibitory effect at 72 h, whereas following the removal of ciprofloxacin and ofloxacin, rapid bacterial multiplication occurred, leading to the destruction of the macrophage monolayer within 48 h. Thus, while pefloxacin, ciprofloxacin, and ofloxacin all inhibited the multiplication of L. pneumophila in human monocyte-derived macrophages, only pefloxacin exhibited a prolonged postantibacterial effect. The inhibitory and postantibacterial activities of pefloxacin, ciprofloxacin, and ofloxacin against virulent Legionella pneumophila serogroup 1 were evaluated in cell-free and cellular models. In the absence of macrophages, bacterial numbers remained unchanged at 24 h in the presence of 0.1 mu g of pefloxacin, ciprofloxacin, or ofloxacin per ml and 1.0 mu g of pefloxacin per ml, whereas they were reduced in the presence of 1.0 mu g of ciprofloxacin per ml. Experiments to evaluate the postantibacterial effects of these drugs were therefore performed with concentrations of 0.1 mu g /ml. In the cell-free model, brief exposure (1 hr) of bacteria to each antimicrobial agent resulted in a transient decrease in numbers followed by logarithmic growth. In the cellular model, all three drugs (at 0.1 and 1.0 mu g/ml) inhibited the intracellular multiplication of L. pneumophila . The intracellular postantibacterial effects of 0.1 mu g of pefloxacin, ciprofloxacin, and ofloxacin per ml, which were left in contact with L. pneumophila -infected human macrophages for 24 h, were evaluated at various times after removal of the drugs. Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC |
Author | J J Pocidalo E Dournon P Rajagopalan-Levasseur G Dameron J L Vilde |
AuthorAffiliation | Hôpital Claude Bernard, Université VII, Institut National de la Santé et de la Recherche Médicale, Unité 13, France |
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Keywords | Antibiotic Microorganism growth Sensitivity resistance Legionellaceae Minimum inhibitory concentration Microorganism culture Bacteria Legionella pneumophila Infected cell Antibacterial agent In vitro Macrophage |
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Reddit... The inhibitory and postantibacterial activities of pefloxacin, ciprofloxacin, and ofloxacin against virulent Legionella pneumophila serogroup 1 were evaluated... |
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SubjectTerms | Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cell Division - drug effects Ciprofloxacin Ciprofloxacin - pharmacology Humans Intracellular Fluid Intracellular Fluid - physiology Legionella Legionella - classification Legionella - drug effects Legionella - physiology Macrophages - physiology Medical sciences Microbial Sensitivity Tests Ofloxacin Ofloxacin - pharmacology Pefloxacin Pefloxacin - pharmacology Pharmacology. Drug treatments Research Article Serotyping Time Factors |
Title | Comparative postantibacterial activities of pefloxacin, ciprofloxacin, and ofloxacin against intracellular multiplication of Legionella pneumophila serogroup 1 |
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