Determination of Low Molecular Weight Silicones in Plasma and Blood of Women after Exposure to Silicone Breast Implants by GC/MS

• Published in: Analytical chemistry (Washington) Vol. 73; no. 3; pp. 606 - 611
• Main Authors: Flassbeck, Daniela, Pfleiderer, Bettina, Grümping, Rainer, Hirner, Alfred V
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.02.2001
• Subjects: Adult; Aged; Analysis of complex biological substances; Analytical, structural and metabolic biochemistry; Biological and medical sciences; Blood; Blood and biological fluids; Blood Chemical Analysis - methods; Breast implants; Female; Fundamental and applied biological sciences. Psychology; Gas chromatography; Gas Chromatography-Mass Spectrometry - methods; Humans; Mammaplasty; Mass spectrometry; Medical sciences; Middle Aged; Molecular Weight; Molecules; Prostheses and Implants; Sample preparation; Silicon; Silicones; Silicones - analysis; Silicones - chemistry; Spectrum analysis; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology. Biomaterials. Equipments; Electron impact; Biological fluid; Biochemical analysis; Breast disease; Coupled method; Silicon Organic compounds; Organic siloxane; Plastic surgery; Solvent extraction; Blood plasma; Whole blood; Gas chromatography; Multicomponent analysis; Sample preparation; Biomaterial; Oxygen silicon heterocycle; Mass spectrometry; Quantitative analysis

A sensitive, one-step sample preparation method for detection of volatile, low molecular weight (LMW) cyclic silicones hexamethylcyclotrisiloxane (D3), octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), and dodecamethylcyclohexasiloxane (D6) in plasma and blood using gas chromatog...