Design, Synthesis, Antibacterial Evaluation, Three-Dimensional Quantitative Structure–Activity Relationship, and Mechanism of Novel Quinazolinone Derivatives

• Published in: Journal of agricultural and food chemistry Vol. 71; no. 9; pp. 3939 - 3949
• Main Authors: Shao, Lihui, Zhao, Su, Yang, Song, Zhou, Xiang, Li, Yan, Li, Chengpeng, Chen, Danping, Li, Zhuirui, Ouyang, Guiping, Wang, Zhenchao
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 08.03.2023
• Subjects: Agricultural and Environmental Chemistry; Anti-Bacterial Agents - chemistry; bioactive properties; copper; Copper - pharmacology; drugs; flow cytometry; food chemistry; leaf blight; Microbial Sensitivity Tests; Oryza - microbiology; Oxadiazoles - pharmacology; Plant Diseases - microbiology; proteomics; Quantitative Structure-Activity Relationship; quantitative structure-activity relationships; reactive oxygen species; rice; Structure-Activity Relationship; therapeutics; Xanthomonas; Xanthomonas oryzae pv. oryzae; mechanism of action; quinazolinone derivatives; CoMFA model; antibacterial assay

Plant bacterial illnesses are common and cause dramatic damage to agricultural goods all over the world, yet there are few efficient bactericides to alleviate them at present. To discover novel antibacterial agents, two series of quinazolinone derivatives with novel structures were synthesized and t...