Molecular Dynamics-Guided Design of a Functional Protein–ATRP Conjugate That Eliminates Protein–Protein Interactions

• Published in: Bioconjugate chemistry Vol. 32; no. 4; pp. 821 - 832
• Main Authors: Kaupbayeva, Bibifatima, Boye, Susanne, Munasinghe, Aravinda, Murata, Hironobu, Matyjaszewski, Krzysztof, Lederer, Albena, Colina, Coray M, Russell, Alan J
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 21.04.2021
• Subjects: Antibodies; Asymmetry; Chimeras; Chymotrypsin; Conjugates; Design; Drug development; Dynamic stability; Enzymes; Fractionation; Light scattering; Molecular dynamics; Molecular sieves; Pancreas; Photon correlation spectroscopy; Polymers; Protein interaction; Protein structure; Proteins; Scattering; Stochasticity; Substrates

Even the most advanced protein–polymer conjugate therapeutics do not eliminate antibody–protein and receptor–protein recognition. Next-generation bioconjugate drugs will need to replace stochastic selection with rational design to select desirable levels of protein–protein interaction while retainin...