Anterior Insula–Associated Social Novelty Recognition: Pivotal Roles of a Local Retinoic Acid Cascade and Oxytocin Signaling

• Published in: The American journal of psychiatry Vol. 180; no. 4; pp. 305 - 317
• Main Authors: Kim, Sun-Hong, An, Kyongman, Namkung, Ho, Saito, Atsushi, Rannals, Matthew D., Moore, James R., Mihaljevic, Marina, Saha, Sneha, Oh, Seyun, Kondo, Mari A., Ishizuka, Koko, Yang, Kun, Maher, Brady J., Niwa, Minae, Sawa, Akira
• Format: Journal Article
• Language: English
• Published: United States American Psychiatric Association 01.04.2023
• Subjects: Brain; Brain - metabolism; Cognition & reasoning; Humans; Information dissemination; Mental disorders; Neurons; Neurons - metabolism; Oxytocin - metabolism; Psychiatry; Receptors, Oxytocin - genetics; Receptors, Oxytocin - metabolism; Social Behavior; Social interaction; Social networks; Retinoic Acid; Anterior Insula; Oxytocin; Serotonin; Social Cognition

Objective:Deficits in social cognition consistently underlie functional disabilities in a wide range of psychiatric disorders. Neuroimaging studies have suggested that the anterior insula is a “common core” brain region that is impaired across neurological and psychiatric disorders, which include so...