Anterior Insula–Associated Social Novelty Recognition: Pivotal Roles of a Local Retinoic Acid Cascade and Oxytocin Signaling
Objective:Deficits in social cognition consistently underlie functional disabilities in a wide range of psychiatric disorders. Neuroimaging studies have suggested that the anterior insula is a “common core” brain region that is impaired across neurological and psychiatric disorders, which include so...
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| Published in | The American journal of psychiatry Vol. 180; no. 4; pp. 305 - 317 |
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| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
American Psychiatric Association
01.04.2023
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| Abstract | Objective:Deficits in social cognition consistently underlie functional disabilities in a wide range of psychiatric disorders. Neuroimaging studies have suggested that the anterior insula is a “common core” brain region that is impaired across neurological and psychiatric disorders, which include social cognition deficits. Nevertheless, neurobiological mechanisms of the anterior insula for social cognition remain elusive. This study aims to fill this knowledge gap.Methods:To determine the role of the anterior insula in social cognition, the authors manipulated expression of Cyp26B1, an anterior insula-enriched molecule that is crucial for retinoic acid degradation and is involved in the pathology of neuropsychiatric conditions. Social cognition was mainly assayed using the three-chamber social interaction test. Multimodal analyses were conducted at the molecular, cellular, circuitry, and behavioral levels.Results:At the molecular and cellular level, anterior insula–mediated social novelty recognition is maintained by proper activity of the layer 5 pyramidal neurons, for which retinoic acid–mediated gene transcription can play a role. The authors also demonstrate that oxytocin influences the anterior insula–mediated social novelty recognition, although not by direct projection of oxytocin neurons, nor by direct diffusion of oxytocin to the anterior insula, which contrasts with the modes of oxytocin regulation onto the posterior insula. Instead, oxytocin affects oxytocin receptor–expressing neurons in the dorsal raphe nucleus, where serotonergic neurons are projected to the anterior insula. Furthermore, the authors show that serotonin 5-HT2C receptor expressed in the anterior insula influences social novelty recognition.Conclusions:The anterior insula plays a pivotal role in social novelty recognition that is partly regulated by a local retinoic acid cascade but also remotely regulated by oxytocin via a long-range circuit mechanism. |
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| AbstractList | Deficits in social cognition consistently underlie functional disabilities in a wide range of psychiatric disorders. Neuroimaging studies have suggested that the anterior insula is a "common core" brain region that is impaired across neurological and psychiatric disorders, which include social cognition deficits. Nevertheless, neurobiological mechanisms of the anterior insula for social cognition remain elusive. This study aims to fill this knowledge gap.OBJECTIVEDeficits in social cognition consistently underlie functional disabilities in a wide range of psychiatric disorders. Neuroimaging studies have suggested that the anterior insula is a "common core" brain region that is impaired across neurological and psychiatric disorders, which include social cognition deficits. Nevertheless, neurobiological mechanisms of the anterior insula for social cognition remain elusive. This study aims to fill this knowledge gap.To determine the role of the anterior insula in social cognition, the authors manipulated expression of Cyp26B1, an anterior insula-enriched molecule that is crucial for retinoic acid degradation and is involved in the pathology of neuropsychiatric conditions. Social cognition was mainly assayed using the three-chamber social interaction test. Multimodal analyses were conducted at the molecular, cellular, circuitry, and behavioral levels.METHODSTo determine the role of the anterior insula in social cognition, the authors manipulated expression of Cyp26B1, an anterior insula-enriched molecule that is crucial for retinoic acid degradation and is involved in the pathology of neuropsychiatric conditions. Social cognition was mainly assayed using the three-chamber social interaction test. Multimodal analyses were conducted at the molecular, cellular, circuitry, and behavioral levels.At the molecular and cellular level, anterior insula-mediated social novelty recognition is maintained by proper activity of the layer 5 pyramidal neurons, for which retinoic acid-mediated gene transcription can play a role. The authors also demonstrate that oxytocin influences the anterior insula-mediated social novelty recognition, although not by direct projection of oxytocin neurons, nor by direct diffusion of oxytocin to the anterior insula, which contrasts with the modes of oxytocin regulation onto the posterior insula. Instead, oxytocin affects oxytocin receptor-expressing neurons in the dorsal raphe nucleus, where serotonergic neurons are projected to the anterior insula. Furthermore, the authors show that serotonin 5-HT2C receptor expressed in the anterior insula influences social novelty recognition.RESULTSAt the molecular and cellular level, anterior insula-mediated social novelty recognition is maintained by proper activity of the layer 5 pyramidal neurons, for which retinoic acid-mediated gene transcription can play a role. The authors also demonstrate that oxytocin influences the anterior insula-mediated social novelty recognition, although not by direct projection of oxytocin neurons, nor by direct diffusion of oxytocin to the anterior insula, which contrasts with the modes of oxytocin regulation onto the posterior insula. Instead, oxytocin affects oxytocin receptor-expressing neurons in the dorsal raphe nucleus, where serotonergic neurons are projected to the anterior insula. Furthermore, the authors show that serotonin 5-HT2C receptor expressed in the anterior insula influences social novelty recognition.The anterior insula plays a pivotal role in social novelty recognition that is partly regulated by a local retinoic acid cascade but also remotely regulated by oxytocin via a long-range circuit mechanism.CONCLUSIONSThe anterior insula plays a pivotal role in social novelty recognition that is partly regulated by a local retinoic acid cascade but also remotely regulated by oxytocin via a long-range circuit mechanism. Objective: Deficits in social cognition consistently underlie functional disabilities in a wide range of psychiatric disorders. Neuroimaging studies have suggested that the anterior insula is a "common core" brain region that is impaired across neurological and psychiatric disorders, which include social cognition deficits. Nevertheless, neurobiological mechanisms of the anterior insula for social cognition remain elusive. This study aims to fill this knowledge gap. Methods: To determine the role of the anterior insula in social cognition, the authors manipulated expression of Cyp26B1, an anterior insula-enriched molecule that is crucial for retinoic acid degradation and is involved in the pathology of neuropsychiatric conditions. Social cognition was mainly assayed using the three-chamber social interaction test. Multimodal analyses were conducted at the molecular, cellular, circuitry, and behavioral levels. Results: At the molecular and cellular level, anterior insula–mediated social novelty recognition is maintained by proper activity of the layer 5 pyramidal neurons, for which retinoic acid–mediated gene transcription can play a role. The authors also demonstrate that oxytocin influences the anterior insula–mediated social novelty recognition, although not by direct projection of oxytocin neurons, nor by direct diffusion of oxytocin to the anterior insula, which contrasts with the modes of oxytocin regulation onto the posterior insula. Instead, oxytocin affects oxytocin receptor–expressing neurons in the dorsal raphe nucleus, where serotonergic neurons are projected to the anterior insula. Furthermore, the authors show that serotonin 5-HT2C receptor expressed in the anterior insula influences social novelty recognition. Conclusions: The anterior insula plays a pivotal role in social novelty recognition that is partly regulated by a local retinoic acid cascade but also remotely regulated by oxytocin via a long-range circuit mechanism. Deficits in social cognition consistently underlie functional disabilities in a wide range of psychiatric disorders. Neuroimaging studies have suggested that the anterior insula is a "common core" brain region that is impaired across neurological and psychiatric disorders, which include social cognition deficits. Nevertheless, neurobiological mechanisms of the anterior insula for social cognition remain elusive. This study aims to fill this knowledge gap. To determine the role of the anterior insula in social cognition, the authors manipulated expression of Cyp26B1, an anterior insula-enriched molecule that is crucial for retinoic acid degradation and is involved in the pathology of neuropsychiatric conditions. Social cognition was mainly assayed using the three-chamber social interaction test. Multimodal analyses were conducted at the molecular, cellular, circuitry, and behavioral levels. At the molecular and cellular level, anterior insula-mediated social novelty recognition is maintained by proper activity of the layer 5 pyramidal neurons, for which retinoic acid-mediated gene transcription can play a role. The authors also demonstrate that oxytocin influences the anterior insula-mediated social novelty recognition, although not by direct projection of oxytocin neurons, nor by direct diffusion of oxytocin to the anterior insula, which contrasts with the modes of oxytocin regulation onto the posterior insula. Instead, oxytocin affects oxytocin receptor-expressing neurons in the dorsal raphe nucleus, where serotonergic neurons are projected to the anterior insula. Furthermore, the authors show that serotonin 5-HT receptor expressed in the anterior insula influences social novelty recognition. The anterior insula plays a pivotal role in social novelty recognition that is partly regulated by a local retinoic acid cascade but also remotely regulated by oxytocin via a long-range circuit mechanism. |
| Author | Rannals, Matthew D. Saha, Sneha Maher, Brady J. Yang, Kun Namkung, Ho Saito, Atsushi Kondo, Mari A. Sawa, Akira Oh, Seyun Niwa, Minae Mihaljevic, Marina Ishizuka, Koko Moore, James R. Kim, Sun-Hong An, Kyongman |
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| CitedBy_id | crossref_primary_10_1093_cercor_bhaf043 crossref_primary_10_1038_s41598_023_38044_6 crossref_primary_10_1176_appi_ajp_20230110 crossref_primary_10_1176_appi_ajp_20230127 crossref_primary_10_1038_s41380_024_02419_6 |
| Cites_doi | 10.3389/fnmol.2018.00027 10.1146/annurev-neuro-071013-014119 10.1074/jbc.M111.263681 10.1016/j.neuron.2011.02.056 10.1186/s13041-020-00605-5 10.1038/s41593-019-0469-1 10.1523/JNEUROSCI.3604-05.2005 10.1126/science.1158668 10.1097/WNP.0000000000000377 10.1016/j.neuron.2014.06.024 10.1007/978-4-431-56077-7_8 10.1016/j.schres.2016.04.018 10.1016/j.neuroimage.2003.11.003 10.1016/j.bbr.2017.07.044 10.1016/j.biopsych.2014.04.015 10.1016/j.tics.2009.05.001 10.1016/j.neuron.2016.03.033 10.1146/annurev-psych-120710-100449 10.1016/j.neuron.2008.08.012 10.1038/s41593-018-0071-y 10.1038/s41380-018-0305-0 10.1016/S0925-4773(01)00463-4 10.1126/science.1252723 10.1016/j.neuron.2011.11.030 10.1093/cercor/bhh070 10.3389/fnhum.2013.00904 10.1074/jbc.M112.361790 10.1038/nrn2555 10.1016/S0028-3908(97)00038-5 10.1152/jn.00049.2012 10.1002/ajp.22875 10.1016/j.tics.2015.10.007 10.1016/j.biopsych.2015.11.021 10.1007/s00429-010-0270-0 10.1016/j.tins.2017.02.002 10.1038/77040 10.1093/schbul/sbn192 10.1523/JNEUROSCI.2944-18.2019 10.1016/j.neuropharm.2012.12.004 10.1146/annurev.ne.06.030183.001413 10.1126/science.aaf7003 10.1016/j.euroneuro.2013.11.008 10.1038/nrn3857 10.1371/journal.pone.0136494 10.1002/cne.11004 10.1146/annurev.psych.121208.131647 10.3389/fpsyg.2015.01805 10.1017/S0033291714002487 10.3389/fpsyt.2014.00179 10.1038/nn.2281 10.1177/1073858410366481 10.1038/nrn2212 10.1038/s41467-017-02173-0 10.1016/j.bbr.2016.10.012 10.1038/s41380-019-0566-2 10.1210/endo.133.3.8396014 10.1146/annurev-nutr-072610-145127 10.1038/nature05526 10.1038/s41593-020-0695-6 10.1523/JNEUROSCI.5593-08.2009 10.1038/nn.3083 10.1038/nature13028 10.1016/j.cub.2017.05.010 10.1093/cercor/bhx211 10.1124/mol.107.038083 10.1126/science.aat8127 10.1016/j.yhbeh.2013.08.012 10.1093/hmg/ddl251 10.1002/cne.902100207 |
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| Keywords | Retinoic Acid Anterior Insula Oxytocin Serotonin Social Cognition |
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| References | Rogers, CN 2018; 80 Numan, M 2005; 25 Forsythe, ID 2010; 16 Nam, CI 2008; 60 Uddin, LQ 2017; 34 Blumberger, DM 2016; 20 Ju, A 2020; 13 Paine, TA 2017; 317 Schneider, M 2016; 90 Zhang, P 2018; 362 Dantzler, HA 2012; 108 Bora, E 2016; 175 Cataldo, I 2018; 11 Kitamura, T 2016; 353 Singer, T 2009; 13 Okuyama, T 2016; 353 Rogers-Carter, MM 2018; 21 Sejourne, J 2015; 10 Swedlow, N 2017; 317 Lichti, U 2012; 125 Nomi, JS 2018; 28 Yip, PK 2006; 15 Shachar-Lavie, I 2013; 7 Sawchenko, PE 1983; 6 Leventhal, MB 2020; 23 Ferris, CF 2005; 25 Dufwenberg, M 2011; 70 Tan, Y 2019; 39 Kuti, OJ 2015; 10 Shergill, SS 2015; 45 Cairns, MJ 2020; 25 Dumais, KM 2013; 64 Anno, YN 2011; 286 Wong, LF 2006; 15 Harden, SW 2019; 39 Qiu, J 2007; 72 McCleery, A 2015; 77 Joshi, A 2015; 77 Bosch, MA 2007; 72 Swetschinski, L 2017; 317 Lee, J 2015; 77 Knobloch, HS 2012; 73 Liu, HX 2007; 446 Hadjimichael, E 2018; 362 Takayanagi, Y 2017; 81 Besnard, A 2017; 8 Mayer, TE 2013; 64 Xue, CH 2007; 72 Oettl, LL 2016; 90 Lempert, KM 2014; 37 Atkins, JR 2020; 25 Jin, D 2007; 446 Nomi, JS 2017; 34 Schettini, E 2018; 28 Hebert-Seropian, B 2017; 34 Santana, N 2004; 14 Bicks, LK 2015; 6 Smith, A 2011; 70 Sokol-Hessner, P 2014; 37 Dolle, P 2001; 107 Uddin, LQ 2015; 16 Frith, CD 2012; 63 Ren, J 2014; 83 Saper, CB 1982; 210 Varela, JA 2018; 21 Wood, MD 1997; 36 Fett, AKJ 2015; 45 Zolfaghari, R 2011; 31 Koenig, JI 2014; 24 Ye, T 2012; 287 Weissbourd, B 2014; 83 Okano, J 2012; 125 Bartels, A 2004; 21 Azhari, A 2018; 11 Serrats, J 2004; 14 Cavalcante, LES 2017; 334 Gogolla, N 2017; 27 Bernard, A 2009; 12 Santana, N 2017; 27 Aoto, J 2008; 60 Pattinson, D 2006; 15 Gribbons, KB 2018; 21 Wilson, CA 2014; 24 Ravi, N 2016; 90 Frith, U 2012; 63 Yoshimura, R 1993; 133 Singhal, SM 2019; 39 DeLoach, KE 2014; 83 Sanfey, AG 2011; 62 MacLean, G 2001; 107 Zinn, CG 2017; 334 Takashima, A 2017; 81 Takayanagi, Y 2009; 29 Raam, T 2017; 8 Bright, F 1997; 36 Preuschoff, K 2009; 13 Krabbendam, L 2015; 45 Kiyama, H 1993; 133 Kennett, GA 1997; 36 Artigas, F 2017; 27 Charlet, A 2012; 73 Craig, ADB 2009; 10 Sahu, SP 2018; 80 Ng, L 2009; 12 Gehrlach, DA 2019; 22 Wu, YF 2020; 13 Yamamuro, K 2020; 23 Rilling, JK 2011; 62 Reay, WR 2020; 25 Air, TM 2014; 5 Esposito, G 2018; 11 Choukrallah, MA 2012; 287 Young, LJ 2008; 322 Kim, SH 2017; 40 Critchley, HD 2009; 13 Steinert, JR 2010; 16 Quide, Y 2020; 25 Daskalakis, ZJ 2016; 20 Chen, L 2014; 78 Barger, BK 2012; 108 Hitti, FL 2014; 508 Kimura, T 1993; 133 Hearn, EF 2000; 25 Klein, AS 2019; 22 Mamiya, S 2012; 125 Poon, MM 2008; 60 Martin, EA 2010; 36 Moutier, E 2012; 287 Downar, J 2016; 20 Lalevee, S 2011; 286 Young, LJ 2000; 25 Dolensek, N 2019; 22 Llaneza, D 2015; 10 Austgen, JR 2012; 108 Sarti, F 2014; 78 Baune, BT 2014; 5 Lau, AG 2014; 78 Akbarian, S 2015; 6 Namkung, H 2017; 40 Hirai, H 2007; 446 Yoshida, M 2009; 29 Pantelis, C 2016; 175 Ross, AC 2011; 31 Ferguson, JN 2000; 25 Young, LJ 2014; 345 Li, QH 2004; 469 Weightman, MJ 2014; 5 Bortolozzi, A 2004; 14 Craig, AD 2010; 214 Broce, I 2018; 28 Swanson, LW 1983; 6 Walker, JB 2010; 36 Chernova, T 2010; 16 Inoue, K 2009; 29 Febo, M 2005; 25 Zeki, S 2004; 21 Meyer-Lindenberg, A 2012; 15 Hoffmann, LC 2012; 73 Lau, C 2009; 12 Gandal, MJ 2018; 362 Bredewold, R 2013; 64 Tanaka-Nakadate, S 2004; 469 Tost, H 2012; 15 Chang, LJ 2011; 70 Phelps, EA 2014; 37 Kohler, CG 2010; 36 Rilling, JK 2014; 345 Maden, M 2007; 8 Abu-Abed, S 2001; 107 Fernandez-Arroyo, B 2020; 13 Gilboa-Schechtman, E 2013; 7 Sawa, A 2017; 40 Roy, DS 2016; 353 Ross, AP 2018; 80 Chatagnon, A 2011; 286 Siegelbaum, SA 2014; 508 Donaldson, ZR 2008; 322 Koike, H 2015; 6 Yoshida, M 2017; 81 McAvoy, KM 2017; 8 Nakadate, K 2004; 469 Bicks, LK 2020; 23 Schmidt, SD 2017; 334 B20 B64 B21 B65 B22 B66 B23 B67 B24 B68 B25 B69 B26 B27 B28 B29 B70 B71 B30 B31 B32 B33 B34 B35 B36 B37 B38 B39 Okano J (B40) 2012; 125 B1 B2 B3 B4 B5 B6 B7 B8 B9 B41 B42 B43 Santana N (B59) 2017; 27 B44 B45 B46 B47 B48 B49 B50 B51 B52 B53 B10 B54 B11 B55 B12 B56 B13 B57 B14 B58 B15 B16 B17 B18 B19 B60 B61 B62 B63 37002691 - Am J Psychiatry. 2023 Apr 1;180(4):262-264. doi: 10.1176/appi.ajp.20230110 |
| References_xml | – volume: 322 start-page: 900 year: 2008 end-page: 904 article-title: Oxytocin, vasopressin, and the neurogenetics of sociality publication-title: Science – volume: 7 start-page: 904 year: 2013 article-title: More than a face: a unified theoretical perspective on nonverbal social cue processing in social anxiety publication-title: Front Hum Neurosci – volume: 6 start-page: 269 year: 1983 end-page: 324 article-title: Hypothalamic integration: organization of the paraventricular and supraoptic nuclei publication-title: Annu Rev Neurosci – volume: 28 start-page: 3445 year: 2018 end-page: 3456 article-title: Structural connections of functionally defined human insular subdivisions publication-title: Cereb Cortex – volume: 23 start-page: 1240 year: 2020 end-page: 1252 article-title: A prefrontal-paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice publication-title: Nat Neurosci – volume: 31 start-page: 65 year: 2011 end-page: 87 article-title: Cytochrome P450s in the regulation of cellular retinoic acid metabolism publication-title: Annu Rev Nutr – volume: 107 start-page: 195 year: 2001 end-page: 201 article-title: Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development publication-title: Mech Dev – volume: 25 start-page: 284 year: 2000 end-page: 288 article-title: Social amnesia in mice lacking the oxytocin gene publication-title: Nat Genet – volume: 8 start-page: 2001 year: 2017 article-title: Hippocampal oxytocin receptors are necessary for discrimination of social stimuli publication-title: Nat Commun – volume: 21 start-page: 1155 year: 2004 end-page: 1166 article-title: The neural correlates of maternal and romantic love publication-title: Neuroimage – volume: 125 start-page: 1827 year: 2012 end-page: 1836 article-title: Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development publication-title: J Cell Sci – volume: 13 start-page: 334 year: 2009 end-page: 340 article-title: A common role of insula in feelings, empathy, and uncertainty publication-title: Trends Cogn Sci – volume: 78 start-page: 3 year: 2014 end-page: 12 article-title: Synaptic retinoic acid signaling and homeostatic synaptic plasticity publication-title: Neuropharmacology – volume: 63 start-page: 287 year: 2012 end-page: 313 article-title: Mechanisms of social cognition publication-title: Annu Rev Psychol – volume: 15 start-page: 663 year: 2012 end-page: 668 article-title: Neural mechanisms of social risk for psychiatric disorders publication-title: Nat Neurosci – volume: 73 start-page: 553 year: 2012 end-page: 566 article-title: Evoked axonal oxytocin release in the central amygdala attenuates fear response publication-title: Neuron – volume: 8 start-page: 755 year: 2007 end-page: 765 article-title: Retinoic acid in the development, regeneration, and maintenance of the nervous system publication-title: Nat Rev Neurosci – volume: 362 start-page: 1265 year: 2018 article-title: Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder publication-title: Science – volume: 77 start-page: 116 year: 2015 end-page: 126 article-title: Meta-analysis of face processing event-related potentials in schizophrenia publication-title: Biol Psychiatry – volume: 286 start-page: 33322 year: 2011 end-page: 33334 article-title: Genome-wide in silico identification of new conserved and functional retinoic acid receptor response elements (direct repeats separated by 5 bp) publication-title: J Biol Chem – volume: 29 start-page: 2259 year: 2009 end-page: 2271 article-title: Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice publication-title: J Neurosci – volume: 60 start-page: 308 year: 2008 end-page: 320 article-title: Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity publication-title: Neuron – volume: 25 start-page: 11637 year: 2005 end-page: 11644 article-title: Functional magnetic resonance imaging shows oxytocin activates brain regions associated with mother-pup bonding during suckling publication-title: J Neurosci – volume: 25 start-page: 284 year: 2000 end-page: 288 article-title: Social amnesia in mice lacking the oxytocin gene publication-title: Nat Genet – volume: 90 start-page: 609 year: 2016 end-page: 621 article-title: Oxytocin enhances social recognition by modulating cortical control of early olfactory processing publication-title: Neuron – volume: 12 start-page: 356 year: 2009 end-page: 362 article-title: An anatomic gene expression atlas of the adult mouse brain publication-title: Nat Neurosci – volume: 12 start-page: 356 year: 2009 end-page: 362 article-title: An anatomic gene expression atlas of the adult mouse brain publication-title: Nat Neurosci – volume: 34 start-page: 300 year: 2017 end-page: 306 article-title: Structure and function of the human insula publication-title: J Clin Neurophysiol – volume: 73 start-page: 553 year: 2012 end-page: 566 article-title: Evoked axonal oxytocin release in the central amygdala attenuates fear response publication-title: Neuron – volume: 13 start-page: 99 year: 2020 article-title: Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex publication-title: Mol Brain – volume: 10 start-page: 59 year: 2009 end-page: 70 article-title: How do you feel—now? The anterior insula and human awareness publication-title: Nat Rev Neurosci – volume: 13 start-page: 334 year: 2009 end-page: 340 article-title: A common role of insula in feelings, empathy, and uncertainty publication-title: Trends Cogn Sci – volume: 25 start-page: 706 year: 2020 end-page: 718 article-title: The role of the retinoids in schizophrenia: genomic and clinical perspectives publication-title: Mol Psychiatry – volume: 90 start-page: 609 year: 2016 end-page: 621 article-title: Oxytocin enhances social recognition by modulating cortical control of early olfactory processing publication-title: Neuron – volume: 36 start-page: 609 year: 1997 end-page: 620 article-title: SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist publication-title: Neuropharmacology – volume: 5 start-page: 179 year: 2014 article-title: A review of the role of social cognition in major depressive disorder publication-title: Front Psychiatry – volume: 78 start-page: 3 year: 2014 end-page: 12 article-title: Synaptic retinoic acid signaling and homeostatic synaptic plasticity publication-title: Neuropharmacology – volume: 83 start-page: 645 year: 2014 end-page: 662 article-title: Presynaptic partners of dorsal raphe serotonergic and GABAergic neurons publication-title: Neuron – volume: 10 start-page: e0136494 year: 2015 article-title: Social behavioral deficits coincide with the onset of seizure susceptibility in mice lacking serotonin receptor 2c publication-title: PLoS One – volume: 22 start-page: 1424 year: 2019 end-page: 1437 article-title: Aversive state processing in the posterior insular cortex publication-title: Nat Neurosci – volume: 62 start-page: 23 year: 2011 end-page: 48 article-title: The neuroscience of social decision-making publication-title: Annu Rev Psychol – volume: 23 start-page: 1240 year: 2020 end-page: 1252 article-title: A prefrontal-paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice publication-title: Nat Neurosci – volume: 25 start-page: 11637 year: 2005 end-page: 11644 article-title: Functional magnetic resonance imaging shows oxytocin activates brain regions associated with mother-pup bonding during suckling publication-title: J Neurosci – volume: 80 start-page: e22875 year: 2018 article-title: Oxytocin- and arginine vasopressin-containing fibers in the cortex of humans, chimpanzees, and rhesus macaques publication-title: Am J Primatol – volume: 25 start-page: 719 year: 2020 end-page: 731 article-title: Polygenic disruption of retinoid signalling in schizophrenia and a severe cognitive deficit subtype publication-title: Mol Psychiatry – volume: 20 start-page: 107 year: 2016 end-page: 120 article-title: The neural crossroads of psychiatric illness: an emerging target for brain stimulation publication-title: Trends Cogn Sci – volume: 25 start-page: 706 year: 2020 end-page: 718 article-title: The role of the retinoids in schizophrenia: genomic and clinical perspectives publication-title: Mol Psychiatry – volume: 11 start-page: 27 year: 2018 article-title: A review of oxytocin and arginine-vasopressin receptors and their modulation of autism spectrum disorder publication-title: Front Mol Neurosci – volume: 21 start-page: 1155 year: 2004 end-page: 1166 article-title: The neural correlates of maternal and romantic love publication-title: Neuroimage – volume: 6 start-page: 1805 year: 2015 article-title: Prefrontal cortex and social cognition in mouse and man publication-title: Front Psychol – volume: 7 start-page: 904 year: 2013 article-title: More than a face: a unified theoretical perspective on nonverbal social cue processing in social anxiety publication-title: Front Hum Neurosci – volume: 6 start-page: 1805 year: 2015 article-title: Prefrontal cortex and social cognition in mouse and man publication-title: Front Psychol – volume: 446 start-page: 41 year: 2007 end-page: 45 article-title: CD38 is critical for social behaviour by regulating oxytocin secretion publication-title: Nature – volume: 22 start-page: 1424 year: 2019 end-page: 1437 article-title: Aversive state processing in the posterior insular cortex publication-title: Nat Neurosci – volume: 8 start-page: 2001 year: 2017 article-title: Hippocampal oxytocin receptors are necessary for discrimination of social stimuli publication-title: Nat Commun – volume: 80 start-page: e22875 year: 2018 article-title: Oxytocin- and arginine vasopressin-containing fibers in the cortex of humans, chimpanzees, and rhesus macaques publication-title: Am J Primatol – volume: 40 start-page: 200 year: 2017 end-page: 207 article-title: The insula: an underestimated brain area in clinical neuroscience, psychiatry, and neurology publication-title: Trends Neurosci – volume: 29 start-page: 2259 year: 2009 end-page: 2271 article-title: Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice publication-title: J Neurosci – volume: 322 start-page: 900 year: 2008 end-page: 904 article-title: Oxytocin, vasopressin, and the neurogenetics of sociality publication-title: Science – volume: 508 start-page: 88 year: 2014 end-page: 92 article-title: The hippocampal CA2 region is essential for social memory publication-title: Nature – volume: 70 start-page: 560 year: 2011 end-page: 572 article-title: Triangulating the neural, psychological, and economic bases of guilt aversion publication-title: Neuron – volume: 72 start-page: 885 year: 2007 end-page: 896 article-title: Serotonin 5-hydroxytryptamine2C receptor signaling in hypothalamic proopiomelanocortin neurons: role in energy homeostasis in females publication-title: Mol Pharmacol – volume: 317 start-page: 542 year: 2017 end-page: 552 article-title: Decreasing GABA function within the medial prefrontal cortex or basolateral amygdala decreases sociability publication-title: Behav Brain Res – volume: 25 start-page: 719 year: 2020 end-page: 731 article-title: Polygenic disruption of retinoid signalling in schizophrenia and a severe cognitive deficit subtype publication-title: Mol Psychiatry – volume: 15 start-page: 3107 year: 2006 end-page: 3118 article-title: Lentiviral vector expressing retinoic acid receptor beta2 promotes recovery of function after corticospinal tract injury in the adult rat spinal cord publication-title: Hum Mol Genet – volume: 27 start-page: 3125 year: 2017 end-page: 3139 article-title: Expression of serotonin2C receptors in pyramidal and GABAergic neurons of rat prefrontal cortex: a comparison with striatum publication-title: Cereb Cortex – volume: 469 start-page: 128 year: 2004 end-page: 140 article-title: Unique expression patterns of 5-HT2A and 5-HT2C receptors in the rat brain during postnatal development: Western blot and immunohistochemical analyses publication-title: J Comp Neurol – volume: 175 start-page: 72 year: 2016 end-page: 78 article-title: Social cognition in schizophrenia in comparison to bipolar disorder: a meta-analysis publication-title: Schizophr Res – volume: 36 start-page: 609 year: 1997 end-page: 620 article-title: SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist publication-title: Neuropharmacology – volume: 446 start-page: 41 year: 2007 end-page: 45 article-title: CD38 is critical for social behaviour by regulating oxytocin secretion publication-title: Nature – volume: 11 start-page: 27 year: 2018 article-title: A review of oxytocin and arginine-vasopressin receptors and their modulation of autism spectrum disorder publication-title: Front Mol Neurosci – volume: 16 start-page: 435 year: 2010 end-page: 452 article-title: Nitric oxide signaling in brain function, dysfunction, and dementia publication-title: Neuroscientist – volume: 334 start-page: 129 year: 2017 end-page: 134 article-title: Modulation of the storage of social recognition memory by neurotransmitter systems in the insular cortex publication-title: Behav Brain Res – volume: 353 start-page: 1536 year: 2016 end-page: 1541 article-title: Ventral CA1 neurons store social memory publication-title: Science – volume: 214 start-page: 395 year: 2010 end-page: 396 article-title: Once an island, now the focus of attention publication-title: Brain Struct Funct – volume: 77 start-page: 116 year: 2015 end-page: 126 article-title: Meta-analysis of face processing event-related potentials in schizophrenia publication-title: Biol Psychiatry – volume: 37 start-page: 263 year: 2014 end-page: 287 article-title: Emotion and decision making: multiple modulatory neural circuits publication-title: Annu Rev Neurosci – volume: 13 start-page: 99 year: 2020 article-title: Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex publication-title: Mol Brain – volume: 287 start-page: 26328 year: 2012 end-page: 26341 article-title: Retinoic acid receptors recognize the mouse genome through binding elements with diverse spacing and topology publication-title: J Biol Chem – volume: 81 start-page: 243 year: 2017 end-page: 251 article-title: Activation of supraoptic oxytocin neurons by secretin facilitates social recognition publication-title: Biol Psychiatry – volume: 16 start-page: 435 year: 2010 end-page: 452 article-title: Nitric oxide signaling in brain function, dysfunction, and dementia publication-title: Neuroscientist – volume: 133 start-page: 1239 year: 1993 end-page: 1246 article-title: Localization of oxytocin receptor messenger-ribonucleic-acid in the rat-brain publication-title: Endocrinology – volume: 72 start-page: 885 year: 2007 end-page: 896 article-title: Serotonin 5-hydroxytryptamine2C receptor signaling in hypothalamic proopiomelanocortin neurons: role in energy homeostasis in females publication-title: Mol Pharmacol – volume: 80 start-page: e22875 year: 2018 article-title: Oxytocin- and arginine vasopressin-containing fibers in the cortex of humans, chimpanzees, and rhesus macaques publication-title: Am J Primatol – volume: 286 start-page: 33322 year: 2011 end-page: 33334 article-title: Genome-wide in silico identification of new conserved and functional retinoic acid receptor response elements (direct repeats separated by 5 bp) publication-title: J Biol Chem – volume: 317 start-page: 542 year: 2017 end-page: 552 article-title: Decreasing GABA function within the medial prefrontal cortex or basolateral amygdala decreases sociability publication-title: Behav Brain Res – volume: 40 start-page: 200 year: 2017 end-page: 207 article-title: The insula: an underestimated brain area in clinical neuroscience, psychiatry, and neurology publication-title: Trends Neurosci – volume: 63 start-page: 287 year: 2012 end-page: 313 article-title: Mechanisms of social cognition publication-title: Annu Rev Psychol – volume: 73 start-page: 553 year: 2012 end-page: 566 article-title: Evoked axonal oxytocin release in the central amygdala attenuates fear response publication-title: Neuron – volume: 469 start-page: 128 year: 2004 end-page: 140 article-title: Unique expression patterns of 5-HT2A and 5-HT2C receptors in the rat brain during postnatal development: Western blot and immunohistochemical analyses publication-title: J Comp Neurol – volume: 45 start-page: 1145 year: 2015 end-page: 1165 article-title: Social neuroscience in psychiatry: unravelling the neural mechanisms of social dysfunction publication-title: Psychol Med – volume: 469 start-page: 128 year: 2004 end-page: 140 article-title: Unique expression patterns of 5-HT2A and 5-HT2C receptors in the rat brain during postnatal development: Western blot and immunohistochemical analyses publication-title: J Comp Neurol – volume: 34 start-page: 300 year: 2017 end-page: 306 article-title: Structure and function of the human insula publication-title: J Clin Neurophysiol – volume: 16 start-page: 435 year: 2010 end-page: 452 article-title: Nitric oxide signaling in brain function, dysfunction, and dementia publication-title: Neuroscientist – volume: 36 start-page: 1009 year: 2010 end-page: 1019 article-title: Facial emotion perception in schizophrenia: a meta-analytic review publication-title: Schizophr Bull – volume: 20 start-page: 107 year: 2016 end-page: 120 article-title: The neural crossroads of psychiatric illness: an emerging target for brain stimulation publication-title: Trends Cogn Sci – volume: 446 start-page: 41 year: 2007 end-page: 45 article-title: CD38 is critical for social behaviour by regulating oxytocin secretion publication-title: Nature – volume: 10 start-page: e0136494 year: 2015 article-title: Social behavioral deficits coincide with the onset of seizure susceptibility in mice lacking serotonin receptor 2c publication-title: PLoS One – volume: 10 start-page: e0136494 year: 2015 article-title: Social behavioral deficits coincide with the onset of seizure susceptibility in mice lacking serotonin receptor 2c publication-title: PLoS One – volume: 353 start-page: 1536 year: 2016 end-page: 1541 article-title: Ventral CA1 neurons store social memory publication-title: Science – volume: 13 start-page: 334 year: 2009 end-page: 340 article-title: A common role of insula in feelings, empathy, and uncertainty publication-title: Trends Cogn Sci – volume: 64 start-page: 693 year: 2013 end-page: 701 article-title: Sex differences in oxytocin receptor binding in forebrain regions: correlations with social interest in brain region- and sex-specific ways publication-title: Horm Behav – volume: 31 start-page: 65 year: 2011 end-page: 87 article-title: Cytochrome P450s in the regulation of cellular retinoic acid metabolism publication-title: Annu Rev Nutr – volume: 39 start-page: 3249 year: 2019 end-page: 3263 article-title: Oxytocin receptors are expressed by glutamatergic prefrontal cortical neurons that selectively modulate social recognition publication-title: J Neurosci – volume: 133 start-page: 1239 year: 1993 end-page: 1246 article-title: Localization of oxytocin receptor messenger-ribonucleic-acid in the rat-brain publication-title: Endocrinology – volume: 64 start-page: 693 year: 2013 end-page: 701 article-title: Sex differences in oxytocin receptor binding in forebrain regions: correlations with social interest in brain region- and sex-specific ways publication-title: Horm Behav – volume: 78 start-page: 3 year: 2014 end-page: 12 article-title: Synaptic retinoic acid signaling and homeostatic synaptic plasticity publication-title: Neuropharmacology – volume: 36 start-page: 1009 year: 2010 end-page: 1019 article-title: Facial emotion perception in schizophrenia: a meta-analytic review publication-title: Schizophr Bull – volume: 29 start-page: 2259 year: 2009 end-page: 2271 article-title: Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice publication-title: J Neurosci – volume: 125 start-page: 1827 year: 2012 end-page: 1836 article-title: Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development publication-title: J Cell Sci – volume: 13 start-page: 99 year: 2020 article-title: Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex publication-title: Mol Brain – volume: 36 start-page: 609 year: 1997 end-page: 620 article-title: SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist publication-title: Neuropharmacology – volume: 287 start-page: 26328 year: 2012 end-page: 26341 article-title: Retinoic acid receptors recognize the mouse genome through binding elements with diverse spacing and topology publication-title: J Biol Chem – volume: 24 start-page: 759 year: 2014 end-page: 773 article-title: Social interaction and social withdrawal in rodents as readouts for investigating the negative symptoms of schizophrenia publication-title: Eur Neuropsychopharmacol – volume: 11 start-page: 27 year: 2018 article-title: A review of oxytocin and arginine-vasopressin receptors and their modulation of autism spectrum disorder publication-title: Front Mol Neurosci – volume: 353 start-page: 1536 year: 2016 end-page: 1541 article-title: Ventral CA1 neurons store social memory publication-title: Science – volume: 24 start-page: 759 year: 2014 end-page: 773 article-title: Social interaction and social withdrawal in rodents as readouts for investigating the negative symptoms of schizophrenia publication-title: Eur Neuropsychopharmacol – volume: 14 start-page: 1100 year: 2004 end-page: 1109 article-title: Expression of serotonin1a and serotonin2a receptors in pyramidal and GABAergic neurons of the rat prefrontal cortex publication-title: Cereb Cortex – volume: 6 start-page: 269 year: 1983 end-page: 324 article-title: Hypothalamic integration: organization of the paraventricular and supraoptic nuclei publication-title: Annu Rev Neurosci – volume: 22 start-page: 1424 year: 2019 end-page: 1437 article-title: Aversive state processing in the posterior insular cortex publication-title: Nat Neurosci – volume: 62 start-page: 23 year: 2011 end-page: 48 article-title: The neuroscience of social decision-making publication-title: Annu Rev Psychol – volume: 108 start-page: 2292 year: 2012 end-page: 2305 article-title: 5-Hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii publication-title: J Neurophysiol – volume: 60 start-page: 308 year: 2008 end-page: 320 article-title: Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity publication-title: Neuron – volume: 14 start-page: 1100 year: 2004 end-page: 1109 article-title: Expression of serotonin1a and serotonin2a receptors in pyramidal and GABAergic neurons of the rat prefrontal cortex publication-title: Cereb Cortex – volume: 16 start-page: 55 year: 2015 end-page: 61 article-title: Salience processing and insular cortical function and dysfunction publication-title: Nat Rev Neurosci – volume: 286 start-page: 33322 year: 2011 end-page: 33334 article-title: Genome-wide in silico identification of new conserved and functional retinoic acid receptor response elements (direct repeats separated by 5 bp) publication-title: J Biol Chem – volume: 21 start-page: 404 year: 2018 end-page: 414 article-title: Insular cortex mediates approach and avoidance responses to social affective stimuli publication-title: Nat Neurosci – volume: 45 start-page: 1145 year: 2015 end-page: 1165 article-title: Social neuroscience in psychiatry: unravelling the neural mechanisms of social dysfunction publication-title: Psychol Med – volume: 133 start-page: 1239 year: 1993 end-page: 1246 article-title: Localization of oxytocin receptor messenger-ribonucleic-acid in the rat-brain publication-title: Endocrinology – volume: 34 start-page: 300 year: 2017 end-page: 306 article-title: Structure and function of the human insula publication-title: J Clin Neurophysiol – volume: 28 start-page: 3445 year: 2018 end-page: 3456 article-title: Structural connections of functionally defined human insular subdivisions publication-title: Cereb Cortex – volume: 25 start-page: 719 year: 2020 end-page: 731 article-title: Polygenic disruption of retinoid signalling in schizophrenia and a severe cognitive deficit subtype publication-title: Mol Psychiatry – volume: 6 start-page: 1805 year: 2015 article-title: Prefrontal cortex and social cognition in mouse and man publication-title: Front Psychol – volume: 508 start-page: 88 year: 2014 end-page: 92 article-title: The hippocampal CA2 region is essential for social memory publication-title: Nature – volume: 83 start-page: 645 year: 2014 end-page: 662 article-title: Presynaptic partners of dorsal raphe serotonergic and GABAergic neurons publication-title: Neuron – volume: 125 start-page: 1827 year: 2012 end-page: 1836 article-title: Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development publication-title: J Cell Sci – volume: 334 start-page: 129 year: 2017 end-page: 134 article-title: Modulation of the storage of social recognition memory by neurotransmitter systems in the insular cortex publication-title: Behav Brain Res – volume: 107 start-page: 195 year: 2001 end-page: 201 article-title: Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development publication-title: Mech Dev – volume: 14 start-page: 1100 year: 2004 end-page: 1109 article-title: Expression of serotonin1a and serotonin2a receptors in pyramidal and GABAergic neurons of the rat prefrontal cortex publication-title: Cereb Cortex – volume: 27 start-page: R580 year: 2017 end-page: R586 article-title: The insular cortex publication-title: Curr Biol – volume: 60 start-page: 308 year: 2008 end-page: 320 article-title: Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity publication-title: Neuron – volume: 334 start-page: 129 year: 2017 end-page: 134 article-title: Modulation of the storage of social recognition memory by neurotransmitter systems in the insular cortex publication-title: Behav Brain Res – volume: 39 start-page: 3249 year: 2019 end-page: 3263 article-title: Oxytocin receptors are expressed by glutamatergic prefrontal cortical neurons that selectively modulate social recognition publication-title: J Neurosci – volume: 15 start-page: 3107 year: 2006 end-page: 3118 article-title: Lentiviral vector expressing retinoic acid receptor beta2 promotes recovery of function after corticospinal tract injury in the adult rat spinal cord publication-title: Hum Mol Genet – volume: 345 start-page: 771 year: 2014 end-page: 776 article-title: The biology of mammalian parenting and its effect on offspring social development publication-title: Science – volume: 39 start-page: 3249 year: 2019 end-page: 3263 article-title: Oxytocin receptors are expressed by glutamatergic prefrontal cortical neurons that selectively modulate social recognition publication-title: J Neurosci – volume: 210 start-page: 163 year: 1982 end-page: 173 article-title: Convergence of autonomic and limbic connections in the insular cortex of the rat publication-title: J Comp Neurol – volume: 21 start-page: 404 year: 2018 end-page: 414 article-title: Insular cortex mediates approach and avoidance responses to social affective stimuli publication-title: Nat Neurosci – volume: 40 start-page: 200 year: 2017 end-page: 207 article-title: The insula: an underestimated brain area in clinical neuroscience, psychiatry, and neurology publication-title: Trends Neurosci – volume: 108 start-page: 2292 year: 2012 end-page: 2305 article-title: 5-Hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii publication-title: J Neurophysiol – volume: 83 start-page: 645 year: 2014 end-page: 662 article-title: Presynaptic partners of dorsal raphe serotonergic and GABAergic neurons publication-title: Neuron – volume: 21 start-page: 404 year: 2018 end-page: 414 article-title: Insular cortex mediates approach and avoidance responses to social affective stimuli publication-title: Nat Neurosci – volume: 81 start-page: 243 year: 2017 end-page: 251 article-title: Activation of supraoptic oxytocin neurons by secretin facilitates social recognition publication-title: Biol Psychiatry – volume: 5 start-page: 179 year: 2014 article-title: A review of the role of social cognition in major depressive disorder publication-title: Front Psychiatry – volume: 345 start-page: 771 year: 2014 end-page: 776 article-title: The biology of mammalian parenting and its effect on offspring social development publication-title: Science – volume: 108 start-page: 2292 year: 2012 end-page: 2305 article-title: 5-Hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii publication-title: J Neurophysiol – volume: 28 start-page: 3445 year: 2018 end-page: 3456 article-title: Structural connections of functionally defined human insular subdivisions publication-title: Cereb Cortex – volume: 70 start-page: 560 year: 2011 end-page: 572 article-title: Triangulating the neural, psychological, and economic bases of guilt aversion publication-title: Neuron – volume: 362 start-page: 1265 year: 2018 article-title: Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder publication-title: Science – volume: 107 start-page: 195 year: 2001 end-page: 201 article-title: Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development publication-title: Mech Dev – volume: 5 start-page: 179 year: 2014 article-title: A review of the role of social cognition in major depressive disorder publication-title: Front Psychiatry – volume: 27 start-page: 3125 year: 2017 end-page: 3139 article-title: Expression of serotonin2C receptors in pyramidal and GABAergic neurons of rat prefrontal cortex: a comparison with striatum publication-title: Cereb Cortex – volume: 23 start-page: 1240 year: 2020 end-page: 1252 article-title: A prefrontal-paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice publication-title: Nat Neurosci – volume: 70 start-page: 560 year: 2011 end-page: 572 article-title: Triangulating the neural, psychological, and economic bases of guilt aversion publication-title: Neuron – volume: 25 start-page: 284 year: 2000 end-page: 288 article-title: Social amnesia in mice lacking the oxytocin gene publication-title: Nat Genet – volume: 12 start-page: 356 year: 2009 end-page: 362 article-title: An anatomic gene expression atlas of the adult mouse brain publication-title: Nat Neurosci – volume: 45 start-page: 1145 year: 2015 end-page: 1165 article-title: Social neuroscience in psychiatry: unravelling the neural mechanisms of social dysfunction publication-title: Psychol Med – volume: 37 start-page: 263 year: 2014 end-page: 287 article-title: Emotion and decision making: multiple modulatory neural circuits publication-title: Annu Rev Neurosci – volume: 25 start-page: 11637 year: 2005 end-page: 11644 article-title: Functional magnetic resonance imaging shows oxytocin activates brain regions associated with mother-pup bonding during suckling publication-title: J Neurosci – volume: 20 start-page: 107 year: 2016 end-page: 120 article-title: The neural crossroads of psychiatric illness: an emerging target for brain stimulation publication-title: Trends Cogn Sci – volume: 287 start-page: 26328 year: 2012 end-page: 26341 article-title: Retinoic acid receptors recognize the mouse genome through binding elements with diverse spacing and topology publication-title: J Biol Chem – volume: 15 start-page: 663 year: 2012 end-page: 668 article-title: Neural mechanisms of social risk for psychiatric disorders publication-title: Nat Neurosci – volume: 8 start-page: 2001 year: 2017 article-title: Hippocampal oxytocin receptors are necessary for discrimination of social stimuli publication-title: Nat Commun – volume: 72 start-page: 885 year: 2007 end-page: 896 article-title: Serotonin 5-hydroxytryptamine2C receptor signaling in hypothalamic proopiomelanocortin neurons: role in energy homeostasis in females publication-title: Mol Pharmacol – volume: 64 start-page: 693 year: 2013 end-page: 701 article-title: Sex differences in oxytocin receptor binding in forebrain regions: correlations with social interest in brain region- and sex-specific ways publication-title: Horm Behav – volume: 175 start-page: 72 year: 2016 end-page: 78 article-title: Social cognition in schizophrenia in comparison to bipolar disorder: a meta-analysis publication-title: Schizophr Res – volume: 37 start-page: 263 year: 2014 end-page: 287 article-title: Emotion and decision making: multiple modulatory neural circuits publication-title: Annu Rev Neurosci – volume: 77 start-page: 116 year: 2015 end-page: 126 article-title: Meta-analysis of face processing event-related potentials in schizophrenia publication-title: Biol Psychiatry – volume: 81 start-page: 243 year: 2017 end-page: 251 article-title: Activation of supraoptic oxytocin neurons by secretin facilitates social recognition publication-title: Biol Psychiatry – volume: 36 start-page: 1009 year: 2010 end-page: 1019 article-title: Facial emotion perception in schizophrenia: a meta-analytic review publication-title: Schizophr Bull – volume: 317 start-page: 542 year: 2017 end-page: 552 article-title: Decreasing GABA function within the medial prefrontal cortex or basolateral amygdala decreases sociability publication-title: Behav Brain Res – volume: 90 start-page: 609 year: 2016 end-page: 621 article-title: Oxytocin enhances social recognition by modulating cortical control of early olfactory processing publication-title: Neuron – volume: 15 start-page: 3107 year: 2006 end-page: 3118 article-title: Lentiviral vector expressing retinoic acid receptor beta2 promotes recovery of function after corticospinal tract injury in the adult rat spinal cord publication-title: Hum Mol Genet – volume: 362 start-page: 1265 year: 2018 article-title: Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder publication-title: Science – ident: B27 doi: 10.3389/fnmol.2018.00027 – ident: B17 doi: 10.1146/annurev-neuro-071013-014119 – ident: B41 doi: 10.1074/jbc.M111.263681 – ident: B45 doi: 10.1016/j.neuron.2011.02.056 – ident: B48 doi: 10.1186/s13041-020-00605-5 – ident: B32 doi: 10.1038/s41593-019-0469-1 – ident: B28 doi: 10.1523/JNEUROSCI.3604-05.2005 – ident: B21 doi: 10.1126/science.1158668 – ident: B13 doi: 10.1097/WNP.0000000000000377 – ident: B25 doi: 10.1016/j.neuron.2014.06.024 – ident: B35 doi: 10.1007/978-4-431-56077-7_8 – ident: B3 doi: 10.1016/j.schres.2016.04.018 – ident: B29 doi: 10.1016/j.neuroimage.2003.11.003 – ident: B47 doi: 10.1016/j.bbr.2017.07.044 – ident: B6 doi: 10.1016/j.biopsych.2014.04.015 – ident: B19 doi: 10.1016/j.tics.2009.05.001 – ident: B51 doi: 10.1016/j.neuron.2016.03.033 – ident: B1 doi: 10.1146/annurev-psych-120710-100449 – ident: B69 doi: 10.1016/j.neuron.2008.08.012 – ident: B33 doi: 10.1038/s41593-018-0071-y – ident: B66 doi: 10.1038/s41380-018-0305-0 – ident: B37 doi: 10.1016/S0925-4773(01)00463-4 – ident: B23 doi: 10.1126/science.1252723 – ident: B24 doi: 10.1016/j.neuron.2011.11.030 – ident: B58 doi: 10.1093/cercor/bhh070 – volume: 27 start-page: 3125 year: 2017 ident: B59 publication-title: Cereb Cortex – ident: B8 doi: 10.3389/fnhum.2013.00904 – ident: B42 doi: 10.1074/jbc.M112.361790 – ident: B15 doi: 10.1038/nrn2555 – ident: B55 doi: 10.1016/S0028-3908(97)00038-5 – ident: B62 doi: 10.1152/jn.00049.2012 – volume: 125 start-page: 1827 year: 2012 ident: B40 publication-title: J Cell Sci – ident: B30 doi: 10.1002/ajp.22875 – ident: B18 doi: 10.1016/j.tics.2015.10.007 – ident: B50 doi: 10.1016/j.biopsych.2015.11.021 – ident: B14 doi: 10.1007/s00429-010-0270-0 – ident: B12 doi: 10.1016/j.tins.2017.02.002 – ident: B22 doi: 10.1038/77040 – ident: B9 doi: 10.1093/schbul/sbn192 – ident: B52 doi: 10.1523/JNEUROSCI.2944-18.2019 – ident: B70 doi: 10.1016/j.neuropharm.2012.12.004 – ident: B44 doi: 10.1146/annurev.ne.06.030183.001413 – ident: B65 doi: 10.1126/science.aaf7003 – ident: B11 doi: 10.1016/j.euroneuro.2013.11.008 – ident: B20 doi: 10.1038/nrn3857 – ident: B56 doi: 10.1371/journal.pone.0136494 – ident: B57 doi: 10.1002/cne.11004 – ident: B2 doi: 10.1146/annurev.psych.121208.131647 – ident: B10 doi: 10.3389/fpsyg.2015.01805 – ident: B4 doi: 10.1017/S0033291714002487 – ident: B7 doi: 10.3389/fpsyt.2014.00179 – ident: B34 doi: 10.1038/nn.2281 – ident: B36 doi: 10.1177/1073858410366481 – ident: B68 doi: 10.1038/nrn2212 – ident: B53 doi: 10.1038/s41467-017-02173-0 – ident: B60 doi: 10.1016/j.bbr.2016.10.012 – ident: B67 doi: 10.1038/s41380-019-0566-2 – ident: B54 doi: 10.1210/endo.133.3.8396014 – ident: B38 doi: 10.1146/annurev-nutr-072610-145127 – ident: B26 doi: 10.1038/nature05526 – ident: B61 doi: 10.1038/s41593-020-0695-6 – ident: B49 doi: 10.1523/JNEUROSCI.5593-08.2009 – ident: B5 doi: 10.1038/nn.3083 – ident: B64 doi: 10.1038/nature13028 – ident: B16 doi: 10.1016/j.cub.2017.05.010 – ident: B46 doi: 10.1093/cercor/bhx211 – ident: B63 doi: 10.1124/mol.107.038083 – ident: B39 doi: 10.1126/science.aat8127 – ident: B31 doi: 10.1016/j.yhbeh.2013.08.012 – ident: B71 doi: 10.1093/hmg/ddl251 – ident: B43 doi: 10.1002/cne.902100207 – reference: 37002691 - Am J Psychiatry. 2023 Apr 1;180(4):262-264. doi: 10.1176/appi.ajp.20230110 |
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| Snippet | Objective:Deficits in social cognition consistently underlie functional disabilities in a wide range of psychiatric disorders. Neuroimaging studies have... Deficits in social cognition consistently underlie functional disabilities in a wide range of psychiatric disorders. Neuroimaging studies have suggested that... Objective: Deficits in social cognition consistently underlie functional disabilities in a wide range of psychiatric disorders. Neuroimaging studies have... |
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| SubjectTerms | Brain Brain - metabolism Cognition & reasoning Humans Information dissemination Mental disorders Neurons Neurons - metabolism Oxytocin - metabolism Psychiatry Receptors, Oxytocin - genetics Receptors, Oxytocin - metabolism Social Behavior Social interaction Social networks |
| Title | Anterior Insula–Associated Social Novelty Recognition: Pivotal Roles of a Local Retinoic Acid Cascade and Oxytocin Signaling |
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