Ferritin Decorated PLGA/Paclitaxel Loaded Nanoparticles Endowed with an Enhanced Toxicity Toward MCF‑7 Breast Tumor Cells

• Published in: Bioconjugate chemistry Vol. 28; no. 4; pp. 1283 - 1290
• Main Authors: Turino, Ludmila N, Ruggiero, Maria R, Stefanìa, Rachele, Cutrin, Juan C, Aime, Silvio, Geninatti Crich, Simonetta
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 19.04.2017
• Subjects: Albumin; Antineoplastic Agents, Phytogenic - administration & dosage; Breast cancer; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Cells; Contrast agents; Contrast Media - administration & dosage; Contrast Media - pharmacokinetics; Cytotoxicity; Decoration; Drug Carriers - chemistry; Drug Delivery Systems - methods; Ferritin; Ferritins - chemistry; Gadolinium; Glycolic acid; Humans; Image enhancement; Magnetic Resonance Imaging; MCF-7 Cells; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - therapeutic use; Paclitaxel; Paclitaxel - administration & dosage; Paclitaxel - pharmacokinetics; Polyglycolic Acid - chemistry; Polylactide-co-glycolide; Proteins; Scavenger Receptors, Class A; Toxicity; Tumor cells; Tumors

Polylactic and glycolic acid nanoparticles (PLGA-NPs), coated with L-ferritin, are exploited for the simultaneous delivery of paclitaxel and an amphiphilic Gd based MRI contrast agent into breast cancer cells (MCF7). L-ferritin has been covalently conjugated to the external surface of PLGA-NPs explo...