Enantioselective C–H Arylation and Vinylation of Cyclobutyl Carboxylic Amides

• Published in: ACS catalysis Vol. 8; no. 3; pp. 2577 - 2581
• Main Authors: Wu, Qing-Feng, Wang, Xiao-Bing, Shen, Peng-Xiang, Yu, Jin-Quan
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 02.03.2018
• Subjects: MPAO ligands; vinylation; cyclobutanes; α-hydrogen atom; C−H activation; C–H activation

Chiral mono-N-protected aminomethyl oxazoline (MPAO) ligands are found to promote enantioselective C–H arylation and vinylation of the cyclobutyl carboxylic acid derivatives via Pd­(II)/Pd­(IV) redox catalysis. This ligand scaffold overcame two important limitations of the previous MPAHA (mono-N-pro...