Gender and Age Influences on Human Brain Mu-Opioid Receptor Binding Measured by PET

• Published in: The American journal of psychiatry Vol. 156; no. 6; pp. 842 - 848
• Main Authors: Zubieta, Jon-Kar, Dannals, Robert F., Frost, J. James
• Format: Journal Article
• Language: English
• Published: Washington, DC American Psychiatric Publishing 01.06.1999; American Psychiatric Association
• Subjects: Adult; Age Factors; Aged; Aging; Amygdala - diagnostic imaging; Amygdala - metabolism; Analgesics, Opioid; Biochemistry; Biological and medical sciences; Brain; Brain - diagnostic imaging; Brain - metabolism; Carbon Radioisotopes; Development. Senescence. Regeneration. Transplantation; Differential and comparative psychology; Female; Fentanyl - analogs & derivatives; Fundamental and applied biological sciences. Psychology; Humans; Male; Middle Aged; Neocortex - diagnostic imaging; Neocortex - metabolism; Neurology; Postmenopause - metabolism; Postmenopause - physiology; Prospective Studies; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Putamen - diagnostic imaging; Putamen - metabolism; Receptors, Opioid, mu - analysis; Receptors, Opioid, mu - metabolism; Reproduction - physiology; Retrospective Studies; Sex Factors; Sexes; Thalamus - diagnostic imaging; Thalamus - metabolism; Tomography, Emission-Computed; Vertebrates: nervous system and sense organs; Radionuclide study; Human; Senescence; Healthy subject; μ Opioid receptor; Sex; Central nervous system; Biological fixation; Age; Comparative study; Neurotransmission; Brain (vertebrata); Positron; Emission tomography
• ISSN: 0002-953X; 1535-7228
• DOI: 10.1176/ajp.156.6.842

OBJECTIVE: Both age and gender are being increasingly recognized as important factors influencing CNS structure and function. However, there are relatively few data on actual neurochemical differences between the sexes in human subjects or on their interaction with age. One of the central neurotrans...