Arsenic Binding to Proteins

• Published in: Chemical reviews Vol. 113; no. 10; pp. 7769 - 7792
• Main Authors: Shen, Shengwen, Li, Xing-Fang, Cullen, William R, Weinfeld, Michael, Le, X. Chris
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 09.10.2013
• Subjects: Analytical chemistry; Animals; Apoptosis - drug effects; Arsenic; Arsenic - chemistry; Arsenic - metabolism; Biochemistry; DNA Repair Enzymes - antagonists & inhibitors; DNA Repair Enzymes - metabolism; Hemoglobins - chemistry; Hemoglobins - metabolism; Kinetics; Metallothionein - metabolism; Protein Binding; Proteins; Proteins - chemistry; Proteins - metabolism; Pyruvate Dehydrogenase Complex - antagonists & inhibitors; Pyruvate Dehydrogenase Complex - metabolism; Review; Speciation; Thioredoxins - chemistry; Thioredoxins - metabolism

An overview of how arsenic binds to proteins is presented from an analytical and biochemical perspective. The binding affinity, kinetics and speciation of arsenic binding are also investigated.