Naturally Occurring A51V Variant of Human Cytochrome c Destabilizes the Native State and Enhances Peroxidase Activity

• Published in: The journal of physical chemistry. B Vol. 123; no. 42; pp. 8939 - 8953
• Main Authors: Lei, Haotian, Bowler, Bruce E
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 24.10.2019

The A51V variant of human cytochrome c is linked to thrombocytopenia 4 (THC4), a condition that causes decreased blood platelet counts. A 1.82 Å structure of the A51V variant shows only minor changes in tertiary structure relative to the wild-type (WT) protein. Guanidine hydrochloride denaturation d...