Molecular Effects of Glycerol on Lipid Monolayers at the Gas–Liquid Interface: Impact on Microbubble Physical and Mechanical Properties
The production and stability of microbubbles (MBs) is enhanced by increasing the viscosity of both the formation and storage solution, respectively. Glycerol is a good candidate for biomedical applications of MBs, since it is biocompatible, although the exact molecular mechanisms of its action is no...
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Published in | Langmuir Vol. 35; no. 31; pp. 10097 - 10105 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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American Chemical Society
06.08.2019
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Abstract | The production and stability of microbubbles (MBs) is enhanced by increasing the viscosity of both the formation and storage solution, respectively. Glycerol is a good candidate for biomedical applications of MBs, since it is biocompatible, although the exact molecular mechanisms of its action is not fully understood. Here, we investigate the influence glycerol has on lipid-shelled MB properties, using a range of techniques. Population lifetime and single bubble stability were studied using optical microscopy. Bubble stiffness measured by AFM compression is compared with lipid monolayer behavior in a Langmuir–Blodgett trough. We deduce that increasing glycerol concentrations enhances stability of MB populations through a 3-fold mechanism. First, binding of glycerol to lipid headgroups in the interfacial monolayer up to 10% glycerol increases MB stiffness but has limited impact on shell resistance to gas permeation and corresponding MB lifetime. Second, increased solution viscosity above 10% glycerol slows down the kinetics of gas transfer, markedly increasing MB stability. Third, above 10%, glycerol induces water structuring around the lipid monolayer, forming a glassy layer which also increases MB stiffness and resistance to gas loss. At 30% glycerol, the glassy layer is ablated, lowering the MB stiffness, but MB stability is further augmented. Although the molecular interactions of glycerol with the lipid monolayer modulate the MB lipid shell properties, MB lifetime continually increases from 0 to 30% glycerol, indicating that its viscosity is the dominant effect on MB solution stability. This three-fold action and biocompatibility makes glycerol ideal for therapeutic MB formation and storage and gives new insight into the action of glycerol on lipid monolayers at the gas–liquid interface. |
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AbstractList | The production and stability of microbubbles (MBs) is enhanced by increasing the viscosity of both the formation and storage solution, respectively. Glycerol is a good candidate for biomedical applications of MBs, since it is biocompatible, although the exact molecular mechanisms of its action is not fully understood. Here, we investigate the influence glycerol has on lipid-shelled MB properties, using a range of techniques. Population lifetime and single bubble stability were studied using optical microscopy. Bubble stiffness measured by AFM compression is compared with lipid monolayer behavior in a Langmuir-Blodgett trough. We deduce that increasing glycerol concentrations enhances stability of MB populations through a 3-fold mechanism. First, binding of glycerol to lipid headgroups in the interfacial monolayer up to 10% glycerol increases MB stiffness but has limited impact on shell resistance to gas permeation and corresponding MB lifetime. Second, increased solution viscosity above 10% glycerol slows down the kinetics of gas transfer, markedly increasing MB stability. Third, above 10%, glycerol induces water structuring around the lipid monolayer, forming a glassy layer which also increases MB stiffness and resistance to gas loss. At 30% glycerol, the glassy layer is ablated, lowering the MB stiffness, but MB stability is further augmented. Although the molecular interactions of glycerol with the lipid monolayer modulate the MB lipid shell properties, MB lifetime continually increases from 0 to 30% glycerol, indicating that its viscosity is the dominant effect on MB solution stability. This three-fold action and biocompatibility makes glycerol ideal for therapeutic MB formation and storage and gives new insight into the action of glycerol on lipid monolayers at the gas-liquid interface. |
Author | Freear, Steven Evans, Stephen D McLaughlan, James R Thomson, Neil H Abou-Saleh, Radwa H Bushby, Richard J Johnson, Benjamin R |
AuthorAffiliation | School of Electronic and Electrical Engineering Biophysics Group, Department of Physics, Faculty of Science Mansoura University Division of Oral Biology, School of Dentistry Molecular and Nanoscale Physics Group, School of Physics and Astronomy Leeds Institute of Medical Research School of Chemistry |
AuthorAffiliation_xml | – name: Leeds Institute of Medical Research – name: Division of Oral Biology, School of Dentistry – name: Biophysics Group, Department of Physics, Faculty of Science – name: Mansoura University – name: Molecular and Nanoscale Physics Group, School of Physics and Astronomy – name: School of Electronic and Electrical Engineering – name: School of Chemistry |
Author_xml | – sequence: 1 givenname: Radwa H orcidid: 0000-0002-8471-2659 surname: Abou-Saleh fullname: Abou-Saleh, Radwa H organization: Mansoura University – sequence: 2 givenname: James R surname: McLaughlan fullname: McLaughlan, James R organization: Leeds Institute of Medical Research – sequence: 3 givenname: Richard J orcidid: 0000-0002-1627-6058 surname: Bushby fullname: Bushby, Richard J organization: School of Chemistry – sequence: 4 givenname: Benjamin R surname: Johnson fullname: Johnson, Benjamin R organization: Molecular and Nanoscale Physics Group, School of Physics and Astronomy – sequence: 5 givenname: Steven orcidid: 0000-0001-7858-4155 surname: Freear fullname: Freear, Steven organization: School of Electronic and Electrical Engineering – sequence: 6 givenname: Stephen D surname: Evans fullname: Evans, Stephen D email: S.D.Evans@leeds.ac.uk organization: Molecular and Nanoscale Physics Group, School of Physics and Astronomy – sequence: 7 givenname: Neil H orcidid: 0000-0001-7332-790X surname: Thomson fullname: Thomson, Neil H email: N.H.Thomson@leeds.ac.uk organization: Division of Oral Biology, School of Dentistry |
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Title | Molecular Effects of Glycerol on Lipid Monolayers at the Gas–Liquid Interface: Impact on Microbubble Physical and Mechanical Properties |
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