Hydrophobic Drug-Triggered Self-Assembly of Nanoparticles from Silk-Elastin-Like Protein Polymers for Drug Delivery

• Published in: Biomacromolecules Vol. 15; no. 3; pp. 908 - 914
• Main Authors: Xia, Xiao-Xia, Wang, Ming, Lin, Yinan, Xu, Qiaobing, Kaplan, David L
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 10.03.2014
• Subjects: Antineoplastic agents; Applied sciences; Biological and medical sciences; Cell Line, Tumor - drug effects; Chemotherapy; confocal laser scanning microscopy; cytotoxicity; doxorubicin; Doxorubicin - administration & dosage; Doxorubicin - chemistry; Drug Carriers - chemistry; Drug Delivery Systems; elastin; Elastin - chemistry; endocytosis; Exact sciences and technology; flow cytometry; Humans; Hydrophobic and Hydrophilic Interactions; hydrophobicity; in vitro studies; inhibitory concentration 50; Medical sciences; Microscopy, Atomic Force; nanoparticles; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Natural polymers; neoplasm cells; Neoplasms - drug therapy; Pharmacology. Drug treatments; Physicochemistry of polymers; polymers; Polymers - chemistry; Proteins; silk; Silk - chemistry; Biological properties; Nanoparticle; Control release polymer; Elastin; Cytotoxicity; Drug carrier; Experimental study; Doxorubicin; In vitro; Hela cell line; Nanoencapsulation; Biological activity; Silk; Biomimetic compound; Internalization; Molecular aggregation; Recombinant protein; Aqueous solution; Subcellular distribution; Tumor cell; Release

Silk-elastin-like protein polymers (SELPs) combine the mechanical and biological properties of silk and elastin. These properties have led to the development of various SELP-based materials for drug delivery. However, SELPs have rarely been developed into nanoparticles, partially due to the complica...