Distinct Polygenic Score Profiles in Schizophrenia Subgroups With Different Trajectories of Cognitive Development

• Published in: The American journal of psychiatry Vol. 177; no. 4; pp. 298 - 307
• Main Authors: Dickinson, Dwight, Zaidman, Sofia R, Giangrande, Evan J, Eisenberg, Daniel P, Gregory, Michael D, Berman, Karen F
• Format: Journal Article
• Language: English
• Published: United States American Psychiatric Association 01.04.2020
• Subjects: Adolescent; Adolescent Development; Adult; Attention Deficit Disorder with Hyperactivity - psychology; Attention deficit hyperactivity disorder; Case-Control Studies; Cluster Analysis; Cognition; Cognition & reasoning; Cognitive ability; Cognitive Dysfunction - genetics; Cognitive Dysfunction - psychology; Disease Progression; Educational Status; Female; Genetic Predisposition to Disease; Humans; Intelligence; Intelligence Tests; Male; Middle Aged; Multifactorial Inheritance; Psychosis; Risk; Schizophrenia; Schizophrenia - genetics; Schizophrenia - physiopathology; Schizophrenic Psychology; Siblings - psychology; Young Adult; Schizophrenia; Genetics; Premorbid IQ; Cognition; Developmental Trajectory; Polygenic Score

Objective:Different cognitive development histories in schizophrenia may reflect variation across dimensions of genetic influence. The authors derived and characterized cognitive development trajectory subgroups within a schizophrenia sample and profiled the subgroups across polygenic scores (PGSs)...