Serotonin Transporter Occupancy of Five Selective Serotonin Reuptake Inhibitors at Different Doses: An [11C]DASB Positron Emission Tomography Study

• Published in: The American journal of psychiatry Vol. 161; no. 5; pp. 826 - 835
• Main Authors: Meyer, Jeffrey H., Wilson, Alan A., Sagrati, Sandra, Hussey, Doug, Carella, Anna, Potter, William Z., Ginovart, Nathalie, Spencer, Edgar P., Cheok, Andy, Houle, Sylvain
• Format: Journal Article
• Language: English
• Published: Washington, DC American Psychiatric Publishing 01.05.2004; American Psychiatric Association
• Subjects: Adult; Antidepressants; Benzylamines; Biological and medical sciences; Carbon Radioisotopes; Carrier Proteins - drug effects; Carrier Proteins - metabolism; Citalopram - pharmacokinetics; Citalopram - therapeutic use; Clinical outcomes; Corpus Striatum - diagnostic imaging; Corpus Striatum - drug effects; Corpus Striatum - metabolism; Cyclohexanols - pharmacokinetics; Cyclohexanols - therapeutic use; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug therapy; Female; Fluoxetine - pharmacokinetics; Fluoxetine - therapeutic use; Humans; Male; Medical sciences; Membrane Glycoproteins - drug effects; Membrane Glycoproteins - metabolism; Membrane Transport Proteins; Mental disorders; Middle Aged; Nerve Tissue Proteins; Neuropharmacology; Paroxetine - pharmacokinetics; Paroxetine - therapeutic use; Pharmacology. Drug treatments; Psychiatry; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Serotonin - metabolism; Serotonin Plasma Membrane Transport Proteins; Serotonin Uptake Inhibitors - pharmacokinetics; Serotonin Uptake Inhibitors - therapeutic use; Sertraline - pharmacokinetics; Sertraline - therapeutic use; Tomography; Tomography, Emission-Computed; Venlafaxine Hydrochloride; Psychotropic; Central nervous system; Anxiety disorder; Reuptake inhibitor; Encephalon; Dose activity relation; Antidepressant agent; Adult; Mechanism of action; Human; Mood disorder; Serotonin; Treatment efficiency; Depression; Basal ganglion; Corpus striatum; Concomitant disease; Chemotherapy; Biological fixation; Tranquillizer; Treatment; Follow up study; Young adult; Neurotransmitter; Typology; Positron emission tomography; Comparative study

OBJECTIVE: Minimum therapeutic doses of paroxetine and citalopram produce 80% occupancy for the serotonin (5-HT) transporter (5-HTT). The authors used [11C]DASB positron emission tomography to measure occupancies of three other selective serotonin reuptake inhibitors (SSRIs) at minimum therapeutic d...