Serotonin Transporter Occupancy of Five Selective Serotonin Reuptake Inhibitors at Different Doses: An [11C]DASB Positron Emission Tomography Study - Meyer, Jeffrey H.; Wilson, Alan A.; Sagrati, Sandra; Hussey, Doug; Carella, Anna; Potter, William Z.; Ginovart, Nathalie; Spencer, Edgar P.; Cheok, Andy; Houle, Sylvain (The American journal of psychiatry, 2004)
Keywords: Adult; Antidepressants; Benzylamines; Biological and medical sciences; Carbon Radioisotopes; Carrier Proteins - drug effects; Carrier Proteins - metabolism; Citalopram - pharmacokinetics; Citalopram - therapeutic use; Clinical outcomes; Corpus Striatum - diagnostic imaging; Corpus Striatum - drug effects; Corpus Striatum - metabolism; Cyclohexanols - pharmacokinetics; Cyclohexanols - therapeutic use; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug therapy; Female; Fluoxetine - pharmacokinetics; Fluoxetine - therapeutic use; Humans; Male; Medical sciences; Membrane Glycoproteins - drug effects; Membrane Glycoproteins - metabolism; Membrane Transport Proteins; Mental disorders; Middle Aged; Nerve Tissue Proteins; Neuropharmacology; Paroxetine - pharmacokinetics; Paroxetine - therapeutic use; Pharmacology. Drug treatments; Psychiatry; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Serotonin - metabolism; Serotonin Plasma Membrane Transport Proteins; Serotonin Uptake Inhibitors - pharmacokinetics; Serotonin Uptake Inhibitors - therapeutic use; Sertraline - pharmacokinetics; Sertraline - therapeutic use; Tomography; Tomography, Emission-Computed; Venlafaxine Hydrochloride; Psychotropic; Central nervous system; Anxiety disorder; Reuptake inhibitor; Encephalon; Dose activity relation; Antidepressant agent; Adult; Mechanism of action; Human; Mood disorder; Serotonin; Treatment efficiency; Depression; Basal ganglion; Corpus striatum; Concomitant disease; Chemotherapy; Biological fixation; Tranquillizer; Treatment; Follow up study; Young adult; Neurotransmitter; Typology; Positron emission tomography; Comparative study