Defects and Chirality in the Nanoparticle-Directed Assembly of Spherocylindrical Shells of Virus Coat Proteins

• Published in: ACS nano Vol. 12; no. 6; pp. 5323 - 5332
• Main Authors: Zeng, Cheng, Rodriguez Lázaro, Guillermo, Tsvetkova, Irina B, Hagan, Michael F, Dragnea, Bogdan
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 26.06.2018
• Subjects: Bromovirus - chemistry; Capsid Proteins - chemistry; Gold - chemistry; Metal Nanoparticles - chemistry; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Models, Molecular; virus-like particles; chirality; packing; nanoparticle-directed assembly; defects

Virus coat proteins of small isometric plant viruses readily assemble into symmetric, icosahedral cages encapsulating noncognate cargo, provided the cargo meets a minimal set of chemical and physical requirements. While this capability has been intensely explored for certain virus-enabled nanotechno...